两种浓度丙泊酚用于腹腔镜胆囊切除术患者药物效应比较  

Pharmacodynamics and dosage of propofol in two concentration during anesthesia of patients with laparoscopic dholecystectomy

作　　者：杨贵英[1] 杨天德[1] 李洪[1] 杜智勇[1] 

机构地区：[1]第三军医大学新桥医院麻醉科,重庆400037

出　　处：《国际麻醉学与复苏杂志》2017年第8期699-701,共3页International Journal of Anesthesiology and Resuscitation

摘　　要：目的比较相同剂量1％丙泊酚与2％丙泊酚用于腹腔镜胆囊切除术患者的药物效应及达到相同药物效应时的药物用量。方法选择拟行腹腔镜胆囊切除术患者100例，采用随机数字表法分为两组（每组50例）：输注1％丙泊酚组（Ⅰ组）、输注2％丙泊酚组（Ⅱ组）。诱导剂量均为2mg/kg，整个麻醉过程中用Narcotrend麻醉深度监护仪监测麻醉深度，诱导完成后根据Narcotrend指数调整两组丙泊酚的泵速。观察患者Narcotrend指数下降到36的时间、意识消失时间、监测诱导开始15min内MAP和HR下降百分比、丙泊酚第1小时用量及停药至Narcotrend指数恢复到65的时间。结果两组患者意识消失时间及Narcotrend指数下降到36的时间Ⅰ组分别为（115±45）s和（136±54）s，Ⅱ组分别为（156±60）s和（183±61）s，Ⅰ组短于Ⅱ组（P〈0．05）。丙泊酚使用总量和丙泊酚第1小时用量Ⅰ组分别为（41±15）mⅠ和（36±10）ml，Ⅱ组的2倍用药量分别为（53±18）ml和（46±15）ml，Ⅱ组的2倍用药量大于Ⅰ组用药量（P〈0．05）。结论2％丙泊酚麻醉药用量的2倍大于1％丙泊酚，而不是等量的，这说明1％丙泊酚的药效可能强于2％丙泊酚，2％丙泊酚经济效益相对较低。Objective To compare the pharmacodynamics and dosage of propofol in different concentration during anesthesia of patients with lapamscopic cholecystectomy. Methods One hundred patients with laparoscopic cholecystectomy were randomly divided into two groups （n=50）. Group I was given 1% propofol （2 mg/kg, iv） and group II was given 2% propofol （2 mg/kg, iv） for anesthesia induction. Depth of anesthesia was monitored by Narcotrend anesthesia depth monitor during the whole procedures. Infusion speed was adjusted through Narcotrend index. The time of consciousness extinction, Narcotrend index value drops to 36, Narcotrend index value recuperates to 65 and the dosage of propofol in first hour were observed and recorded. The drop percentage of MAP and HR within 15 min after induction starts were also assessed. Results The time of consciousness extinction, and Narcotrend index value drops to 36 were （115±45） s and （136±54） s respectively in group I , and were （156±60） s and （183±61） s respectively in group II. The values in group I are significantly shorter than values in Group II （P〈0.05）. The total dosage and the dosage of propofol in first hour of group I were （41±15） ml and （36±10） ml respectively. The double volume of total dosage and double volume dosage of propofol in first hour were （53±18） ml and （46±15） ml respectively in group II. The double dosage volume of group II is more than total dosage volume of group I （P〈0.05）. Conclusions The potency of 1% propofol is stronger than 2% propofol.

关 键 词：丙泊酚 药物浓度 

分 类 号：R614[医药卫生—麻醉学]