T细胞死亡相关基因8的研究进展  

The research progress of T cell death associated gene 8

作　　者：马晓冬[1] 邵东华[1] 杭黎华[1] 陈正[1] 

机构地区：[1]江苏大学附属人民医院麻醉科,镇江212002

出　　处：《国际麻醉学与复苏杂志》2017年第8期763-768,I0001,共7页International Journal of Anesthesiology and Resuscitation

基　　金：镇江市社会发展项目（SH2014087）

摘　　要：背景T细胞死亡相关基因8（T cell death associated gene 8, TDAG8）受体是一种质子敏感的G蛋白耦联受体（G protein coupled receptor, GPCR），在机体内广泛表达，但其生物学功能和临床相关性仍不十分清楚。随着对TDAG8的研究不断深入，尤其是TDAG8变构激动剂和变构拮抗剂的发现，为揭示TDAG8的生理功能和作用提供了重要的研究工具。目的通过论述TDAG8可能介导的作用及其机制，为进一步研究阐述TDAG8的生物学功能及其临床相关性提供重要的理论依据。内容系统性地综述TDAG8的生理功能及其作用机制。趋向TDAG8可能是炎症反应的重要调节器。Background T cell death associated gene 8 （TDAG8） is a proton sensing G protein coupled receptor which was widely expressed in the body. However, its biological function and clinical relevance still remain unknown. With the advances of research on TDAG8, especially the discovery of allosteric agonists and negative allosteric modulators of TDAG8 which provided important tools for further research, the physiological function and role of TDAG8 were gradually exposed. Objective This review focuses on several functions may regulated by TDAG8 and demonstrates biological function and clinical relevance of TDAG8. This summary provides important theoretical basis for further research. Content Systematically introduce TDAG8 physiological function and mechanism. Trend TDAG8 inflammation may be a critical mediator of inflammation.

关 键 词：T细胞死亡相关基因8 G蛋白耦联受体 变构激动剂 变构拮抗剂 

分 类 号：R392[医药卫生—免疫学]