胎膜早破孕妇血清脂多糖结合蛋白和白细胞介素-6的变化情况与绒毛膜羊膜炎的关系分析  

Changes of serum LBP and IL-6 in pregnant women with premature rupture of membranes and their relationship with chorioamnionitis

作　　者：颜蓉[1] 陈秀堂 杨青[1] 王丹[1] 涂飞霞[1] 

机构地区：[1]安吉县人民医院妇产科,浙江湖州313300

出　　处：《中华医院感染学杂志》2017年第16期3771-3774,共4页Chinese Journal of Nosocomiology

基　　金：浙江省医药卫生基金资助项目(2014KYB254)

摘　　要：目的探讨胎膜早破孕妇血清脂多糖结合蛋白(LBP)、白细胞介素-6(IL-6)变化情况及与绒毛膜羊膜炎的关系。方法选择2014年1月-2015年12月足月胎膜早破孕妇80例为观察组1,未足月胎膜早破孕妇80例为观察组2,同期正常足月孕妇80例为对照组,采用酶联免疫吸附测定(ELISA)法测定血清LBP和IL-6水平。结果观察组1和观察组2血清LBP和IL-6水平均高于对照组(P<0.05),观察组2血清LBP和IL-6水平高于观察组1(P<0.05);观察组1和观察组2孕妇绒毛膜羊膜炎的感染率分别为25.0%、36.3%高于对照组3.8%;胎膜早破患者中,绒毛膜羊膜炎孕妇血清LBP和IL-6水平高于无绒毛膜羊膜炎组(P<0.05);绒毛膜羊膜炎Ⅱ级和Ⅲ级孕妇血清LBP水平高于绒毛膜羊膜炎Ⅰ级(P<0.05),绒毛膜羊膜炎Ⅲ级孕妇血清LBP水平高于绒毛膜羊膜炎Ⅱ级(P<0.05)。结论胎膜早破孕妇血清LBP和IL-6水平升高,未足月胎膜早破孕妇血清LBP和IL-6水平升高更显著;胎膜早破合并绒毛膜羊膜炎孕妇血清LBP水平升高,且与绒毛膜羊膜炎的程度有关。OBJECTIVE To investigate the changes of lipopolysaccharide binding protein （LBP） and interleukin-6 （IL-6） and their relationship with chorioamnionitis in pregnant women with premature rupture of membranes.METHODS A total of 80 cases of pregnant women with premature rupture of membranes were selected as observation group 1, 80 cases of preterm women with premature rupture of membranes were selected as observation group 2, and 80 cases of normal full-term pregnant women were selected as control group.The serum LBP and IL-6 levels were measured by enzyme-linked immunosorbent assay（ELISA）.RESULTS The serum LBP and IL-6 levels of observation group 1 and observation group 2 were higher than those of control group （P＆lt;0.05）.The levels of serum LBP and IL-6 in observation group 2 were higher than those in observation group 1 （P＆lt;0.05）.The infection rates of chorioamnionitis in observation group 1 and observation group 2 were 25.0% and 36.3%, which were higher than 3.8% in control group.In patients with premature rupture of membranes, the levels of serum LBP and IL-6 of chorioamnionitis group were higher than those of no chorioamnionitis group（P〈0.05）;the levels of serum LBP in patients with grade Ⅱ and grade Ⅲ chorioamnionitis were higher than that in grade Ⅰ （P〈0.05）, the serum LBP level of chorioamnionitis Ⅲ was higher than that of chorioamnion Ⅱ （P〈0.05）.CONCLUSION The serum LBP and IL-6 levels of pregnant women with premature rupture of membranes are increased, the serum LBP and IL-6 levels of preterm women with premature rupture of membranes are increased more significantly, the serum LBP level of premature rupture of membranes with chorioamnionitis maternal is increased, and is related to the degree of chorioamnionitis.

关 键 词：胎膜早破 绒毛膜羊膜炎 脂多糖结合蛋白 白细胞介素-6 

分 类 号：R714.433[医药卫生—妇产科学]