高血压病患者不同程度脑白质疏松与认知功能的关系  

Relationship between different degree of leukoaraiosis and cognitive functions in patients with hypertension

作　　者：韦柠琳[1] 阳洪[1] 彭日红[1] 吴钢[1] 刘立民[2] 

机构地区：[1]广西医科大学第四附属医院神经内科,广西柳州545005 [2]广西医科大学第四附属医院检验科,广西柳州545005

出　　处：《华夏医学》2017年第4期8-10,共3页Acta Medicinae Sinica

基　　金：广西壮族自治区卫计委科学基金项目资助(Z2015146)

摘　　要：目的:研究高血压病患者不同程度脑白质疏松(LA)与认知功能之间的关系。方法:将满足入组条件的高血压病患者按照头颅MRI结果将其分为脑白质疏松组43例及无脑白质疏松组31例,进行MMSE及Mo CA评分。比较各组间认知功能评分的差异及相关性。结果:随着LA程度加重,则MMSE、Mo CA评分越低,差异具有统计学意义(P<0.05)。LA与MMSE及Mo CA评分负相关(r分别为-0.585、-0.647,P均<0.01)。结论:高血压病患者LA程度与认知功能障碍的程度相关,随LA程度加重,认知功能障碍越重。Objective： To study the relationship between leukoaraiosis and cognitive functions in hypertension patients. Methods： Patients with essential hypertension were divided into two groups according to MRI results,including 43 cases of leukoaraiosis group,and 31 cases in non-leukoaraiosis group. They were scored with montreal cognitive assessment scale（ Mo CA） and mini-mental state examination（ MMSE）.The differences and correlations of cognitive function assessment were compared between the two groups.Results： The scores of MMSE and Mo CA decreased as the increasing severity of LA,which were of statistical differences between both groups（ P〈0. 05）. The correlation analysis showed LA was negative correlated with MMSE and Mo CA scoring（ r =-0.585,r =-0.647 respectively,P〈0.01）. Conclusion： The severity of LA is closely related to the severity of cognitive disorder,and cognitive disorder increased with the severity of LA.

关 键 词：脑白质疏松 MMSE MOCA 高血压病 

分 类 号：R544.1[医药卫生—心血管疾病]