基于肝毒性的雷公藤中药复方配伍减毒的研究进展  

Study on attenuating hepatotoxicity of Tripterygium wilfordii through compatibility of traditional Chinese medicine compound

作　　者：刘莹[1,2] 仲青香 邱辉辉[2,3] 汪刚[1,2] 王程成[2,3] 封亮[2] 贾晓斌[2,3] 

机构地区：[1]安徽中医药大学药学院,安徽合肥230012 [2]江苏省中医药研究院国家中医药管理局中药释药系统重点研究室,江苏南京210028 [3]南京中医药大学第三临床医学院,江苏南京210028

出　　处：《中国中药杂志》2017年第16期3044-3048,共5页China Journal of Chinese Materia Medica

基　　金：国家中医药管理局2015年公益性行业科研专项(201507004-10);国家自然科学基金项目(81202906;81473394;81403121)

摘　　要：随着中药毒理学研究的不断深入,雷公藤导致肝毒性的作用机制逐渐被揭示。中药配伍作为中医用药的特色之一,在减毒方面具有合理性和科学性。基于肝毒性,笔者对现阶段雷公藤毒性物质基础及机制的研究进行总结与展望,对配伍中药(制剂)以减轻雷公藤毒性的作用进行归纳,以期为雷公藤临床用药的合理性与安全性提供参考,从而减轻肝脏不良反应。With the deepening of the study of toxicology of traditional Chinese medicine,the mechanism of hepatotoxicity caused by Tripterygium wilfordii has been gradually revealed. As one of the characteristics of traditional Chinese medicine,Chinese medicine compatibility show its more reasonable and scientific effect in terms of reducing toxicity. In this paper,the author summarizes the research on the basis and mechanism of toxic substances in T. wilfordii,and sum up the compatibility of traditional Chinese medicine（ preparation） to reduce its role of hepatotoxicity,so as to provide reference for the rationality and safety in clinical application of T.wilfordii,thereby reducing liver adverse reactions.

关 键 词：雷公藤 肝毒性 配伍减毒 机制 

分 类 号：R285.1[医药卫生—中药学]