纳米雄黄外用治疗肠癌溃破创面的临床观察  

The Clinical Observation of Nano-realgar on Wound Induced by Colorectal Cancer

作　　者：王海媚 刘寨东[2] 

机构地区：[1]山东中医药大学中医学院,山东济南250014 [2]山东中医药大学附属医院,山东济南250011

出　　处：《中医药导报》2017年第16期61-63,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家科技支撑计划课题(2015BAI04B10)

摘　　要：目的:探讨纳米雄黄外用治疗肠癌溃破创面的临床疗效。方法:将52例肠癌溃破创面患者随机分为两组,对照组26例口服康复新液,同时清洁换药后湿敷浓度为3%的平阳霉素溶液;治疗组26例在口服康复新液的基础上加用纳米雄黄外涂。观察治疗后两组有效率、相关肿瘤标志物水平以及不良并发症的情况。结果:治疗组总有效率为46.15%(12/26),显著高于对照组的26.92%(7/26)(P<0.05);两组血清CEA、CA199及CA724水平均明显降低(P<0.01),但组间比较,差异均无统计学意义(P>0.05);治疗组并发症发生率为23.08%(6/26),明显低于对照组的46.15%(12/26)(P<0.01)。结论:纳米雄黄外敷对肠癌溃破创面有较好的治疗效果,能减轻患者痛苦,促进肿瘤溃破创面愈合。Objective： To evaluate the effectiveness of realgar nanoparticles which for external use for malignant ulcer in colorectal cancer. Methods： The 52 patients with wound indused by of colorectal cancer were divided into 2 groups, the control group 26 cases was treated with oral Kangfuxin （康复新液）, cleanly therapeutics and then wet packing with 3% pingyangmycin solution. The observation group 26 cases were given nano-realgar on the basis of oral rehabilitation. The effect, the levels of serum tumor markers and complication rate was observed after the treatment. Results： The total effective rate of observation group was 46.15% （12/26）, significantly higher than 26.92% （7/26） in the control group （P〈0.05）; The levels of serum CEA, CA199 and CA724 were significantly lower（P〈0.01）, but there was no significant difference between the groups （P〈0.01）; The complication rate of the treatment group was 23.07%, significantly lower than 46.15% in the control group （P〈0.01）. Conclusion： Nano-realgar is a good treatment for wound induced by colorectal cancer, it can reduce the pain of the patient and promote the healing of the tumor.

关 键 词：纳米雄黄 肠癌溃破创面 肿瘤标志物水平 不良反应 

分 类 号：R273[医药卫生—中西医结合]