中药内服处方治疗儿童抽动障碍的用药规律研究  

Analysis on Medication Rule in Herbal Prescriptions for Children Tic Disorder

作　　者：潘碧琦[1] 刘嘉芬[1] 邱少红[1] 陈凤媚[1] 

机构地区：[1]广东省妇幼保健院,广东广州510010

出　　处：《中医药导报》2017年第16期78-80,84,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：广东省中医药局科研项目(No.20121004)

摘　　要：目的:分析儿童抽动障碍的中药内服处方的用药规律。方法:通过中国知网、重庆维普、万方、中国生物医学文献数据库搜集2013—2016年治疗儿童抽动障碍的中药处方,采用TCMISS中医传承辅助平台软件提取分析处方中各药物的使用频次、四气五味归经、归类以及药物之间的关联规则等进行。结果:对129个中药处方进行分析,使用频率较高的中药有钩藤、甘草、天麻、芍药、茯苓、黄芩、夜交藤、栀子、石决明、桑寄生、杜仲、茯神、牛膝、益母草等。药物的四气分布主要为平、温、凉。药物的五味分布主要为甘、苦、辛。药物的归经分布主要为肝、肺、脾。处方中药物的归类分布主要为茜草科、唇形科、豆科、伞形科、兰科。钩藤、天麻、石决明、夜交藤、黄芩、茯神、牛膝、栀子、杜仲、桑寄生、益母草等均为临床治疗儿童抽动障碍的最常用中药。结论:中药治疗儿童抽动障碍以平肝熄风、清热养阴、补益肝肾为主要治法,常用处方为天麻钩藤饮,关键药物组合是天麻与钩藤,处方用药应以"熄风定惊平肝阳、补泄有序勿留邪"为则。Objective： To analyze the medication rule in herbal prescriptions for children tie disorder. Methods： Herbal prescriptions for children tic disorder were searched from Chinese National Knowledge Infrastructure, VIP database, Wanfang database and Chinese Biomedical Database, from 2013 to 2016. We used Chinese medicine inheritance support system （TCMISS） to analyze the frequency, four natures, five flavors, meridian entry, plant classification of drugs, and the association rules between drugs. Results： Based on the analysis of 129 herbal prescriptions, herbs used with high frequency were Gouteng （Ramuli Umcariae Cure Uneis）, Gancao （Radix Liquiritiae）, Tianma （Rhizoma Gastrodiae）, Shaoyao （Chinese Herbaceous Peony）, Fuling （Poria Cocos）, Huangqin （Scutellaria Baicalensis）, Yejiaoteng （Caulis Polygoni Muhiflori）, Zhizi （Cape Jasmine）, Shijueming （the Shell of Abalone or Sea-ear）, Sangjisheng （Parasitic Loranthus）, Duzhong （Eucommia）, Fushen （Poria with Host- wood）, Niuxi （Radix Achyranthis Bidentatae）, Yimucao （Motherwort）, et al. Four natures of drugs were mainly consist of neutral, warmth and coolness. Five flavors of drugs were mainly consist of sweet, bitter and pungent. Meridian entrys were mainly consist of liver, lung and spleen. Plant classification of drugs were mainly consist of Rubiaceae, Lamiaceae, Leguminosae. Ramuli Umcariae Cure Uncis, Rhizoma Gastrodiae, the Shell of Abalone or Sea-ear, Caulis Polygoni Muhiflori, Scutellaria Baicalensis, Poria with Hostwood, Radix Achyranthis Biden- tatae, Cape Jasmine, Eucommia, Parasitic Loranthus, Motherwort, et al. were the most commonly used traditional Chinese Medicine for children tic disorder. Conclusion： The main principles of treatment for children tic disorder is calming the liver to stop the wind, clearing heat, nourishing yin and tonifying the liver and kidney. The most commonly used traditional Chinese medicine prescription was Tianma Gouteng Decoction. The key drug combination are Rhiz

关 键 词：儿童抽动障碍 慢惊风 组方规律 关联规则 聚类算法 

分 类 号：R272[医药卫生—中医儿科学]