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机构地区:[1]南京中医药大学第一附属医院/江苏省中医院,江苏南京210029
出 处:《中医药导报》2017年第16期100-102,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy
基 金:南京市科委科技计划重点项目(201503012)
摘 要:目的:观察保肾片对造影剂肾病患者尿素、肌酐及β2-微球蛋白水平的影响。方法:选取符合标准的患者80例,随机分为两组各40例。术前予降压药、抗血小板药及他汀类药物治疗。术前常规检查、术后24 h及72 h测定尿素、肌酐及血、尿β2-微球蛋白、肾小球滤过率(e GFR)。结果:两组术后24 h各项指标比较,差异均无统计学意义(P>0.05);两组术后72 h比较,治疗组尿素、肌酐、尿β2-微球蛋白均低于对照组(P<0.01或P<0.05),e GFR高于对照组(P<0.01);治疗组术后72 h尿素、肌酐、血β2-微球蛋白均低于术前(P<0.05或P<0.01),e GFR高于术前(P<0.01)。结论:保肾片能降低冠脉介入术后尿素、肌酐、血及尿β2-微球蛋白,提高e GFR,降低CIN的发生,对造影剂介导的肾损害有预防作用。Objective: To observe the effect of Baoshen Tablet on the levels of urea, creatinine and β2- microglohulin(132-MG) in patients with contrast-induced nephropathy (CIN). Methods: The 80 patients were enrolled in this study, 40 patients in each group. Each group of patients admitted to routine examination, preoperative antihypertensive drugs, anti-platelet drugs and statin therapy. Detect the urea, creatinine, glomerular filtra- tion rate (eGFR) and β2-MG in blood and in urine before operation, at 24 hours and 72 hours after operation. Results: There was no significant difference between the two groups at 24 hours after operation; at 72 hours after operation two groups of indicators were significantly different, compared with the control group: urea and creatinine decreased significantly (P〈0.01), 132-MG in urinary decreased (P〈0.05), eGFR significantly increased (P〈O.O1); in the administration group, the indicators at 72 hours after operation was compared with the indicators before operation: urea decreased (P〈0.05), creatinine and β2-MG in blood decreased significantly (P〈0.01), β2- MG in urinary decreased, eGFR significantly increased (P〈0.01) Conclusion:Baoshen tablet can reduce the urea, creatinine, β2-MG in blood and in urine after coronary intervention, increase eGFR, reduce the occurrence of CIN, and prevent the renal injury caused by contrast media.
分 类 号:R256.5[医药卫生—中医内科学]
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