Anti-promastigote Activity of the Amazon Plants  

作　　者：Silva-Silva, J. V Monteiro, R. C. S. Brigido, H. P. C Vale, V. V Silvestre, J. V. Silva, N. C. S Silveira,F.T Marinho, A. M. R Dolabela, M. F 

机构地区：[1]Programa de Pos-Graduagao em Ciencias Farmacduticas, Universidade Federal do Para, Belem 66075-110, Brasil [2]Programa de Pos-Graduacao em lnovacao Farmaceutica, Universidade Federal do Para, Belem 66075-110, Brasil [3]Faculdade de Ciencias Farmaeeuticas, Universidade Federal do Parr, Belem 66075-11 O, Brasil [4]Instituto Evandro Chagas, Br 316 Km 7, Ananindeua 67030-000, Brasil [5]Faculdade de Qulmica, Universidade Federal do Para, Belem 66075-110, Brasil

出　　处：《Journal of Pharmacy and Pharmacology》2017年第9期654-660,共7页药剂与药理学（英文版）

摘　　要：This study evaluated in vitro activity of ethanol extract, fractions, and isolated substance from Amazon species against promastigotes of L. amazonensis. The ethanol extracts were concentrated and fractionation. The anti-promastigote activity was evaluated through the cell viability assessment method （MTT）. The ethanol extract, fractions, and isolated substance from Himatanthus articulatus and Parahancorniafasciculata were inactive in promastigote ofL. amazonensis, as the ethanol extract ofPhysalis angulata. The hexane fractions from different parts ofMontrichardia linifera showed anti-promastigote activity probably due to the presence of steroids and terpenes. All species in studies were inactive, except ofM. linifera. The few polar constituents can be responsible for the activity. Therefore, the isolation and purification of the active on L. amazonensis promastigotes are urgently required.

关 键 词：LEISHMANIA himatanthus articulatus parahancomia fasciculata montrichardia linifera physalis angulata. 

分 类 号：Q93-333[生物学—微生物学] TQ658[化学工程—精细化工]