血小板膜糖蛋白及脂质过氧化物水平变化在急性冠状动脉综合征发病中的意义  

Significances of platelet membrane glycoprotein and lipid peroxide in pathogenesis of acute coronary syndrome

作　　者：马建林[1] 马向杰[1] 马立宁[1] 张家明[2] 周燕[1] 林劲[1] 张敬文[1] 王圣[1] 李斌[1] 陈关良[1] 王卫[1] 

机构地区：[1]海南省人民医院心内科,海口570311 [2]华中科技大学同济医学院附属协和医院心内科,武汉430022

出　　处：《中国医药》2017年第9期1318-1321,共4页China Medicine

基　　金：海南省自然科学基金（20158328）

摘　　要：目的观察急性冠状动脉综合征（ACS）患者血小板膜糖蛋白（GP）及脂质过氧化物丙二醛水平的变化并评估其临床意义。方法选择2015年1月至2016年6月于海南省人民医院确诊为冠状动脉粥样硬化性心脏病患者116例，其中ACS患者80例（ACS组），稳定型心绞痛（SAP）患者36例（SAP组）；选择同期冠状动脉造影正常的志愿者42例为对照组。比较3组GPⅠb、Ⅱb、Ⅲa和血小板颗粒膜蛋白140（GMP-140）及丙二醛水平。结果ACS组GPⅠb、Ⅱb、Ⅲa及GMP-140水平均高于对照组和SAP组（均P〈0．01）；对照组与SAP组GPⅠb、Ⅱb、Ⅲa及GMP-140水平比较，差异均无统计学意义（P〉0．05）。SAP组及ACS组丙二醛水平均高于对照组[（22±6）、（34±6）μmol／L比（15±4）μmol／L]，ACS组丙二醛水平高于SAP组，差异有统计学意义（P〈0．05）。结论ACS患者体内GP及丙二醛水平明显升高，可能是其发生冠状动脉事件的重要因素，而SAP患者体内GP水平无明显升高，也可能是其预后较好的重要因素。Objective To assess the significances of platelet membrane glycoprotein（GP） and lipid peroxide malondialdehyde（MDA） in patients with acute coronary syndrome（ACS）. Methods From January 2015 to June 2016, 116 patients with coronary atherosclerotic heart disease were enrolled at Hainan General Hospital, including 80 cases of ACS and 36 cases of stable angina pectoris（SAP） ; 42 volunteers with normal coronary angiography were enrolled as control group. Levels of GPⅠb, Ⅱb, Ⅲa, platelet granule membrane protein-140（GMP-ldO） and MDA were analyzed. Results Levels of GPⅠb, Ⅱb, Ⅲa and GMP-140 in ACS group were significantly higher than those in control group and SAP group（P 〈0.01 ）. There were no significant differences of GPⅠb, Ⅱb, Ⅲa and GMP-140 levels between control group and SAP group（P 〉0.05）. The level of MDA in SAP group and ACS group was significantly higher than that in the control group[ （22 ±6）, （34 ±6） μmol/L vs （ 15 ±4） μmol/L] ; the level of MDA in ACS group was significantly higher than that in SAP group （P 〈 0.05 ）. Conclusions Levels of GP and MDA increase in patients with ACS, which may be an influence factor of the occurrence of coronary events. Patients with SAP show no significant change of the level of GP and have better prognosis.

关 键 词：急性冠状动脉综合征 血小板膜糖蛋白类 脂质过氧化物 

分 类 号：R541[医药卫生—心血管疾病]