灯盏花素对血脂检验项目的干扰  

The Analytical Interference of Breviscapine on Blood Lipid Test Items

作　　者：朱峰[1] 桓伟华[2] 张强[1] 张金香[1] 张娜[1] 王立平[1] 

机构地区：[1]河北省沧州中西医结合医院实验诊断科,河北沧州061000 [2]河北省青县人民医院,河北青县062650

出　　处：《标记免疫分析与临床》2017年第8期947-950,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：目的研究灯盏花素对甘油三酯(TG)、总胆固醇(TCHO)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)检测方法的干扰作用。方法严格按照CLSI制定的EP7-A2分析干扰实验方案,通过干扰筛选和剂量效应实验,研究注射用灯盏花素对TG、TCHO、HDL和LDL检测方法是否存在干扰,并明确干扰程度与药物浓度之间的关系。结果注射用灯盏花素对TG、TCHO、HDL、LDL的常用检测方法有较强的负向干扰。结论注射用灯盏花素对TG、TCHO、HDL和LDL常用检测方法的测定会产生干扰,且最小干扰浓度分别为129.5μg/mL、16.16μg/mL、32.38μg/mL和32.38μg/mL。Objective To study the interference of Breviscapine on common methods of triglyceride （TG）, total cholesterol （TCHO）, high density cholesterol （HDL） and low density cholesterol （LDL）.Methods According to the analytical interference project EP7-A2 made by CLSI, interference filter and dose-effect experiments were used to study whether there was analytical interference of injecting Breviscapine on TG, TCHO, HDL, LDL, and to determine the relationship between the interference degree and the drug concentration.Results Injecting Breviscapine had a strong negative interference on TG, TCHO, HDL, LDL.Conclusion Injecting Breviscapine had interference on common methods of inspection items on TG, TCHO, HDL, LD and the minimum interference concentrations were respectively 64.75 μg/mL, 129.5 μg/mL （1∶160）, 16.16 μg/mL （1∶1280）, 32.38 μg/mL （1∶640） and 32.38 μg/mL （1∶640）.

关 键 词：注射用灯盏花素 EP7-A2 分析干扰 干扰筛选 剂量效应实验 

分 类 号：R446.11[医药卫生—诊断学]