真空冷冻干燥技术在提高药物新剂型稳定性中的应用  

Applications of Vacuum Freeze-drying Technology in New Pharmaceutical Preparations

作　　者：曾莹[1] 陈颖[2] 伍善广[3] 

机构地区：[1]广东药科大学,广州510006 [2]广东食品药品职业学院,广州510520 [3]广西科技大学,柳州545006

出　　处：《海峡药学》2017年第8期4-6,共3页Strait Pharmaceutical Journal

基　　金：2015年度广东省医学科研基金项目(A2015260)

摘　　要：随着药物新剂型的广泛应用,解决其系统不稳定性,延长其贮存时间对药物新剂型的发展具有深远意义。冷冻干燥技术可以解决一些药物新剂型长期贮存容易发生沉降、絮凝、聚结、变质的问题,提高其稳定性,因此药物新剂型与真空冷冻干燥技术联用,具有广阔的应用前景。笔者对真空冷冻干燥技术的原理及特点、药物新剂型的特点和优势进行介绍,并对近年来冻干技术在药物新剂型领域中的应用进行了综述。With New pharmaceutical preparations be widely applied, it has a profound meaning on the develop- ment of New pharmaceutical preparations to enhance the stability and extend storage time of it. Vacuum freeze-drying technology can solve sedimentation,floeeulation,coalescence and metamorphism on drug and enhance its stability, so combining New pharmaceutical preparations with Vacuum freeze-drying technology is common and has a wide appli- cation prospect. This article introduces the features and principle of New pharmaceutical preparations and Vacuum freeze-drying technology and reviews the recent applications of Vacuum freeze-drying technology in New pharmaceuti- cal preparations.

关 键 词：真空冷冻干燥技术 药物新剂型 稳定性 

分 类 号：R944[医药卫生—药剂学]