太赫兹光谱技术用于肺癌检测的初步探索研究  

Terahertz spectroscopy for lung cancer detection: a preliminary study

作　　者：刘丁瑗[1] 施长城[2] 周向东[1] 

机构地区：[1]第三军医大学西南医院呼吸内科,重庆400038 [2]中国科学院重庆绿色智能技术研究院,重庆400714

出　　处：《第三军医大学学报》2017年第17期1739-1743,共5页Journal of Third Military Medical University

基　　金：工程物理与生物医学交叉实验室孵化基金(2010年)~~

摘　　要：目的利用太赫兹光谱技术,对人肺癌组织进行检测,比较肺癌组织、癌旁组织及正常肺组织之间的差异,筛选出具有特异性诊断价值的太赫兹频段,初步探索太赫兹光谱技术用于肺癌的早期检测。方法收集2015年6月至2015年12月经我院胸外科手术切除、病理明确诊断为Ⅰ~ⅢA期非小细胞肺癌患者30例,其肺癌组织病理类型为:腺癌17例、鳞癌10例、大细胞肺癌2例、肉瘤样癌1例。每组包括同一患者肺癌组织、癌旁组织及正常肺组织。运用频段为0.2~2.0 THz的太赫兹光谱进行检测,对比3类组织标本对太赫兹光谱的吸收率。结果 (1)肺癌组织对太赫兹光谱吸收率显著高于正常肺组织;(2)太赫兹光谱频段1.4~2.0 THz可能为具有肺癌特异性诊断价值的太赫兹频段。结论鉴于肺癌组织对太赫兹光谱吸收率高于正常肺组织,太赫兹光谱技术可能成为一种新型非侵入诊断肺癌的检测技术,其具有特异性诊断价值的太赫兹频段可能为1.4~2.0 THz。Objective To preliminarily explore the detection of lung cancer by comparing the differences among normal lung tissues with terahertz spectroscopy and screen the application of terahertz spectroscopy in the early lung cancer tissues, paracancerous tissues, and suitable terahertz frequency for specific diagnosis of lung cancer. Methods Thirty groups of lung tissue samples from non-small cell lung cancer patients at stage of Ⅰ to Ⅲ A were collected, and each group contained lung cancer tissue, paracancerous tissues, and normal lung tissue from the same patient. These lung cancer specimens included 17 cases of adenoearcinoma, 10 cases of squamous cell carcinoma, 2 cases of large cell lung cancer, and 1 case of sareomatoid carcinoma. Terahertz spectroscopy from 0.2 THz to 2.0 THz was used to detect these tissue samples, and the absorption coefficient was compared. Results The absorption coefficient was significantly higher in the lung cancer tissues than the normal lung tissues. （2） Terahertz spectroscopy at a frequency of 0.8 to 1.4 THz may have the specific diagnostic value of lung cancer. Conclusion Since the absorption rate is higher in the lung cancer than the normal lung tissue, which is suggested that terahertz spectroscopy may be regarded as a novel non- invasive diagnostic approach for lung cancer. The specific diagnostic value of the terahertz frequency may be 1.4 -2.0 THz for lung cancer.

关 键 词：太赫兹光谱技术 非小细胞肺癌 吸收率 

分 类 号：O433.4[机械工程—光学工程] R730.9[理学—光学]