丹参注射液对子痫前期患者血清D-二聚体、雌激素及对胎盘循环影响研究  

Effects of Danshen Injection on Serum D-dimer,Estrogen and Placental Circulation in Preeclampsia Patients

作　　者：焦波[1] 

机构地区：[1]三亚市妇幼保健院,海南三亚572000

出　　处：《辽宁中医杂志》2017年第8期1688-1691,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的:探讨丹参注射液对子痫前期患者血清D-二聚体、雌激素及对胎盘循环的影响。方法:选取该院产科2013年3月—2015年12月诊断为子痫前期(孕龄<34周)患者68例,按随机数字表法分组,分别34例,对照组予以常规硫酸镁、镇静、降压治疗;研究组在硫酸镁、镇静、降压治疗上予以丹参注射液治疗,共治疗1周为1个疗程,采血测定血清氧化应激、胎盘相关、血液流变学以及性激素等指标,同时观察并记录临床相应指标及并发症状况。结果:与治疗前比较,两组治疗后血清SOD、CAT含量升高,MDA、LPO含量降低,治疗后血清IGF-1、PLGF含量升高,治疗后HBV、LBV、PV、ERI以及D二聚体含量降低,治疗后血清E2、E2/Pg含量升高,Pg含量降低(P<0.05);与对照组比较,研究组治疗后血清SOD、CAT含量较高,MDA、LPO含量较低,治疗后血清IGF-1、PLGF含量较高,治疗后HBV、LBV、PV、ERI以及D二聚体含量较低,治疗后血清E2、E2/Pg含量较高,Pg含量较低(P<0.05);研究组新生儿存活率91.18%(31/34),对照组新生儿存活率70.59%(24/34),研究组高于对照组(P<0.05)。研究组分娩孕周、胎盘质量、存活新生儿体质量、存活新生儿1 min Apgar评分高于对照组(P<0.05)。结论:丹参注射液治疗子痫前期患者的疗效显著,调节内皮功能,改善雌激素及胎盘循环,促进分娩新生儿预后。Objective： To investigate the effects of Danshen Injection on serum D-dimer,estrogen and placental circulation in patients with preeclampsia. Methods： Sixty-eight patients with preeclampsia（ gestational age 34 weeks） from March 2013 to December 2015 were selected and divided into 2 groups according to the method of random number table. The control group was given conventional magnesium sulfate,sedation,blood pressure and antihypertensive therapy. The study group was treated more with Danshen Injection,and 2 groups were treated for 1 week. Levels of serum oxidative stress,placenta,hemorheology and sex hormones were measured,corresponding clinical indicators and complications were compared. Results： Compared with before treatment,levels of serum SOD,CAT and MDA and LPO in the 2 groups decreased,and levels of serum IGF-1 and PLGF increased,levels of HBV,LBV,PV,ERI and D dimer decreased,levels of serum E2,E2/Pg increased,levels of Pg decreased（ P〈0. 05）.Compared with the control group,the levels of serum SOD,CAT and MDA,LPO in the study group were lower,levels of serum IGF-1 and PLGF were higher,levels of HBV,LBV,PV,ERI and D dimer were lower,levels of serum E2,E2/Pg were higher,and levels of Pg were lower（ P〈0. 05）,and the neonatal survival rate in the study group＇ s 91. 18%（ 31/34） was higher than the control group＇s 70. 59%（ 24/34）（ P〈0. 05）. The gestational weeks,the quality of placenta,the body weight of surviving neonates and the Apgar score of surviving neonates in the study group were higher than those of the control group（ P〈0. 05）. Conclusion： Danshen Injection is effective in the treatment of preeclampsia,regulating endothelial function,improving estrogen and placental circulation,and promoting the prognosis of neonates.

关 键 词：丹参注射液 子痫前期 D-二聚体 雌激素 胎盘循环 

分 类 号：R285.6[医药卫生—中药学]