新诊断2型糖尿病合并高尿酸血症患者颈围水平及临床意义  

Analysis of neck circumference and clinical significance in newly diagnosed type 2 diabetes patients with hyperuricemia

作　　者：钱唯韵[1] 刘飞[1] 陆亚华[1] 汪良芝[1] 

机构地区：[1]常州市第一人民医院干部一科,江苏常州213003

出　　处：《常州实用医学》2017年第4期211-215,共5页CHANGZHOU PRACTICAL MEDICINE

摘　　要：目的探讨新诊断2型糖尿病（T2DM）合并高尿酸血症（HUA）患者颈围水平及临床意义。方法选择研究对象90例，其中正常对照组（NC组）30例，单纯2型糖尿病组（T2DM组）30例，2型糖尿病合并高尿酸血症组（T2DM＋HUA组）30例。所有研究对象测量颈围，行口服葡萄糖耐量试验（OGTF），并检测血糖、血脂等相关生化指标。结果T2DM合并HUA组患者的颈围为38．31±2．89cm，大于NC组33．20±1．92cm及单纯T2DM组36．61±3．29cm（P〈0．05或P〈0．01）。随着颈围水平的增大，血尿酸水平显著升高（P〈0．05或0．01），高尿酸血症发病率明显上升（P〈0．01）。简单相关分析显示，尿酸与颈围、体重指数（BMI）、腰围（WC）、收缩压（SBP）、舒张压（DBP）、空腹血糖（FPG）、餐后2小时血糖（2hPG）、空腹胰岛素（FINS）、餐后2h胰岛素（PSI）、甘油三酯（TG）及胰岛素抵抗指数（HOMA—IR）呈正相关（P〈0．05或P〈0．01），与高密度脂蛋白（HDL—C）呈显著负相关（P〈0．01）。Logistic回归分析显示，颈围是T2DM合并HUA的危险因素，随着颈围水平的上升，T2DM合并HUA的危险程度增加（P〈0．01）。结论新诊断T2DM合并HUA患者颈围明显增加，且颈围是T2DM合并HUA的危险因素。Objective To investigate neck circumferences in patients with type 2 diabetes mellitus （T2DM） with hyperuricemia（HUA）, and to study the clinical significance. Methods A total of 90 subjects were enrolled in the study, including 30 healthy subjects and 60 patients with newly-diagnosed type 2 diabetes（T2DM） which were divided into T2DM group（n=30） and T2DM with HUA group（n=30）. Oral glucose tolerance test（OGTT） and insulin releasing test were performed in all subjects, meanwhile, neck circumference, blood lipid, blood uric acid and other items were measured. Results Compared with control group and T2DM group, the neck circumference was increased in HUA＋T2DM group[（ 38.31±2.89 ） vs （33.20±1.92） cm,（ 38.31± 2.89） vs （36.61±3.29） cm, P〈0.05 or P 〈0.01, respectively]. Subjects in the upper neck circumference fertile had higher levels of blood uric acid and HUA incidence. The uric acid was positively correlated with neck circumference, BMI, WC, SBP, DBP, FPG, 2hPG, FINS, PSI, TG and HOMA-IR, while negatively correlated with HDL-C（P〈0.05 or P 〈0.01）. Binary logistic regression analyses demonstrated that neck circumference was significantly associated with T2DM and HUA even after adjustment for age, sex, BMI, WC, blood pressure, blood glucose and blood insulin and lipid profile（P〈0.01）. Conclusion Newly-diagnosed type 2 diabetes mellitus patients with HUA tend to have bigger neck circumference, the neck circumference was the risk factor for T2DM with HUA

关 键 词：新诊断2型糖尿病 高尿酸血症 颈围 临床意义 

分 类 号：R589.7[医药卫生—内分泌]