文拉法辛对慢性COPD合并抑郁症患者生活质量的影响  

作　　者：龙瀛[1] 胡建平[1] 

机构地区：[1]遂宁市中心医院呼吸科,四川遂宁629000

出　　处：《中国医疗设备》2017年第B04期194-195,共2页China Medical Devices

摘　　要：目的研究文拉法辛对慢性COPD合并抑郁症患者生活质量的影响，探讨其临床应用价值。方法随机选取我院在2014年09月-2015年12月期间收治的慢性COPD合并抑郁症患者60例，按照治疗方式的差异性将患者分为观察组和对照组，观察组患者应用噻托嗅胺联合文拉法辛治疗COPD合并抑郁症患者，对照组采用常规安慰剂治疗，对比两组患者的治疗效果即SDS量表的评分结果，对比两组患者对生活质量的满意度。结果观察组患者的抑郁自评量表的评分为51±1．3，对照组的评分为60±2．6，两组患者数据对比有明显差异，有统计学意义（P〈0．05）；观察组患者对生活质量的满意程度为78％，对照组的满意程度为96％，具有统计学意义（P〈o．05）。结论文拉法辛对慢性COPD合并抑郁症患者的治疗效果显著，抑郁情况和生活质量有明显改善，值得在临床上推广应用。Objective： To study the effect of venlafaxine on the quality of life in patients with chronic COPD and depression. Methods： randomly selected from our hospital in 60 patients with chronic COPD associated with depression in 2014 09 months to December 2015 were selected from the patients, according to different treatment methods of the patients were divided into observation group and control group, the observation group was treated with tiotropium bromamine combined with venlafaxine in the treat ment of COPD patients with depression, the control group using conventional placebo treatment, comparison the therapeutic effect of two groups of SDS scale scores, com- pared two groups of patients satisfaction on quality of life. Results： the observation group of patients with self rating Depression Scale score was 51 ±1.3, the control group score was 60 ± 2.6, compared to two group of patient data. There was obvious difference was statistically significant （P〈 0.05） ;the observation group of patients satisfaction with quality of life satisfaction was 78%, the control group was 96% with statistical significance （P〈0.05）. Conclusion： the therapeutic effect of venlafaxine on chronic COPD patients with depression were significantly improved quality of life and depression, it is worthy of clinical application.

关 键 词：文拉法辛 抑郁 生活质量 

分 类 号：R453[医药卫生—治疗学]