血清白细胞介素-6水平在慢性肾脏病病人中的变化及与糖尿病的相关性研究  

Study on the change of serum IL-6 level in patients with chronic kidney disease and its relationship with diabetes

作　　者：徐雅虹[1] 蒋茜[1] 王雅楠[1] 曾洋[1] 沈杰[1] 周蓉[1] 

机构地区：[1]同济大学附属杨浦医院上海市杨浦区中心医院肾内科,上海200090

出　　处：《蚌埠医学院学报》2017年第6期725-727,731,共4页Journal of Bengbu Medical College

基　　金：上海市卫计委资助项目(20144Y0224)

摘　　要：目的:观察慢性肾脏病(CKD)1~5期非透析病人血清白细胞介素(IL)-6的水平及其影响因素,并探讨其与糖尿病的相关性。方法:选取CKD病人57例,分为CKD早期组[肾小球滤过率≥60 m L·min^(-1)·(1.73 m2)-1]14例和CKD晚期组[肾小球滤过率<60 m L·min^(-1)·(1.73 m2)-1]43例,测定各组血清IL-6水平,分析其与一般生化指标间的关联。同时根据有无糖尿病病史,分为合并糖尿病CKD组(20例)和无糖尿病CKD组(37例)进行亚组分析。结果:CKD早期组血清IL-6、血尿酸、脑利钠肽及甲状旁腺激素水平均低于CKD晚期组(P<0.05~P<0.01),而血红蛋白水平则显著高于CKD晚期组(P<0.01)。CKD病人的血清IL-6水平同尿白蛋白(ALB)呈正相关关系(P<0.05)。合并糖尿病CKD病人糖化血红蛋白、IL-6、尿ALB水平均高于非糖尿病CKD病人(P<0.05)。结论:不同分期的CKD病人血清IL-6水平存在显著差异。合并糖尿病CKD病人的血清IL-6水平较无糖尿病CKD病人显著升高。尿ALB是影响CKD病人血清IL-6水平的重要因素。Objective： To investigate the level of serum interleukin-6（ IL-6） in patients with stage 1 to 5 chronic kidney disease（ CKD）,its influencing factors,and correlation of IL-6 level with diabetes. Methods： A total of 57 patients with CKD were divided into the early CKD group[14 cases,glomerular filtration rate（ GFR） ≥60 m L·min^（-1）·（ 1. 73 m2）-1] and late CKD group[43 cases,GFR 60 m L·min^（-1）·（ 1. 73 m2）-1]. The levels of IL-6 in two groups were detected,and the correlation of which with general biochemistry indicators wss analyzed. Meanwhile,the patients were divided into the CKD complicated with diabetes group（ 20 cases）and CKD non-complicated with diabetes group（ 37 cases） according to the diabetes history,respectively,and the clinical data of two groups were analyzed. Results： The levels of serum IL-6,blood uric acid,serum brain natriuretic peptide and parathyroid hormone in early CKD group were significantly lower those in late CKD group,but the level of hemoglobin in early CKD group was significantly higher than that in late CKD group（ P〈0. 05 to P〈0. 01）. The level of serum IL-6 was positively correlated with urine albumin（ P〈0. 05）.The levels of glycosylated hemoglobin,IL-6 and urine albumin in CKD patients complicated with diabetes were significantly higher than those in CKD patients non-complicated with diabetes（ P〈0. 05）. Conclusions： There is a significant difference of serum IL-6 level in different stages CKD patients. Compared with the CKD patients non-complicated with diabetes,the IL-6 level in CKD patients complicated with diabetes significantly increases. The urine albumin plays an important role in the serum level of IL-6 in CKD patients.

关 键 词：肾疾病 糖尿病 白细胞介素-6 尿白蛋白 

分 类 号：R699.2[医药卫生—泌尿科学]