血清肝素结合表皮生长因子mRNA水平与急性冠状动脉综合征的关系  

Relationship Between Serum mR NA Level of Heparin Binding Epidermal Growth Factor and Acute Coronary Syndrome Occurrence

作　　者：韩鹏黎[1] 程晓丹[2] 刘建华[2] 刘新叶[2] 池豪[2] 曹巍[1] 杨东伟[2] 

机构地区：[1]郑州大学附属郑州中心医院转化医学中心,河南省郑州市450007 [2]郑州大学附属郑州中心医院心血管内科,河南省郑州市450007

出　　处：《中国循环杂志》2017年第8期748-751,共4页Chinese Circulation Journal

基　　金：河南省科技厅科技攻关项目(142102310460)

摘　　要：目的:探讨血清中肝素结合表皮生长因子(HB-EGF)信使核糖核酸(mRNA)水平与急性冠状动脉(冠脉)综合征的关系。方法:采用逆转录-聚合酶链式反应(RT-PCR)检测50例急性冠脉综合征患者(ACS组)及100例正常对照组(NC组)血清中HB-EGF mRNA的表达水平,运用Logistic回归分析评估其与急性冠脉综合征的关系。结果:与NC组相比,ACS组患者的HB-EGF mRNA水平较高(0.22±0.73 vs 0.46±0.14,P<0.05)。校正高血压、吸烟、甘油三酯、总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、体重指数等单因素分析中有意义的因素后,HB-EGF mRNA水平与急性冠脉综合征有关(比值比=5.813,95%可信区间:2.342~14.426,P<0.001),即HB-EGF mRNA每增加0.1个灰度值,急性冠脉综合征风险增加4.813倍。结论:血清中HB-EGF mRNA水平升高与急性冠脉综合征有关。Objective： To evaluate the relationship between serum mRNA level of heparin binding epidermal growth factor（HBEGF） and acute coronary syndrome（ACS） occurrence. Methods： Our research included in 2 groups： ACS group, n=50 patients and Control group, n=100 normal subjects. Serum HB-EGF mRNA level was examined by RT-PCR and the relationship between HB-EGF m RNA and ACS occurrence was assessed by Logistic regression analysis. Results： Compared with Control group, the serum HB-EGF mRNA level of ACS group was higher（0.22±0.73） vs（0.46±0.14）, P〈0.05. With adjusted meaningful factors of hypertension, smoking, TG, TC, LDL-C, HDL-C and BMI by single factor analysis, multi Logistic regression analysis indicated that serum HB-EGF mRNA was related to ACS occurrence（OR=5.813, 95% CI 2.342-14.426, P〈0.001） which meant that upon 0.1 grey value of HB-EGF mRNA elevation, the risk of ACS occurrence may increase 4.813 folds accordingly.Conclusion： Serum HB-EGF mRNA level was related to ACS occurrence.

关 键 词：肝素结合表皮生长因子 RNA 信使 急性冠状动脉综合征 

分 类 号：R54[医药卫生—心血管疾病]