EB病毒感染对儿童传染性单核细胞增多症T细胞亚群的影响  

Influence of Epstein-Barr virus infection on T cell subset in children with infectious mononucleosis

作　　者：崔强华[1] 孙莉[1] 吴琳[1] 方萍[2] 

机构地区：[1]陕西省汉中市人民医院儿科,723000 [2]西安交通大学第二附属医院呼吸内科,西安710004

出　　处：《重庆医学》2017年第25期3491-3493,共3页Chongqing medicine

基　　金：国家自然科学基金资助项目(81000009)

摘　　要：目的观察EB病毒(EBV)感染对儿童传染性单核细胞增多症(IM)T细胞亚群的影响。方法选取2013年1月至2016年1月陕西省汉中市人民医院儿科收治的80例IM患儿作为研究对象,所有患儿均接受抗病毒治疗,观察患儿治疗后的EBV-DNA转阴率。比较EBV-DNA阳性及阴性患儿的T细胞亚群分布,分析EBV-DNA未转阴的相关因素。结果经过治疗后,67例(83.75%)患儿EBV-DNA转阴。治疗后,EBV-DNA阴性组CD3^+和CD8^+比例低于EBV-DNA阳性组,CD4^+比例和CD4^+/CD8^+高于EBV-DNA阳性组,差异有统计学意义(P<0.05)。对患儿EBV-DNA未转阴的相关因素进行分析:性别、白细胞计数(WBC)及淋巴细胞计数与EBV-DNA转阴无相关性(P>0.05),干扰素的使用、年龄及初始Ct与EBV-DNA未转阴具有相关性(P<0.05)。结论 EB病毒感染可以引起IM患儿T细胞亚群的紊乱,临床上应采取积极的抗病毒治疗。Objective To observe the influence of Epstein-Barr virus（EBV） infection on T cell subsets in children with infec- tious mononucleosis（IM）. Methods Eighty children patients with IM in the Hanzhong Municipal People＇s Hospital from January 2013 to January 2016 were chosen as the study subjects and received the anti-virus therapy. The negative conversion rate of EBV- DNA after treatment was observed. The distributions of T cell subsets were compared b.etween the children patients with EBV- DNA positive and patients with EBV-DNA negative. The related factors of EBV-DNA non-negative conversion were analyzed. Re- suits After treatment,67 children cases （83.75%） were EBV-DNA negative conversion. The proportions of CD3＋ and CD8＋ after treatment in the EBV-DNA negative group were lower than those in the EBV-DNA positive group,and the proportion of CD4＋ and CD4＋/CD8＋ were higher than those in the EBV DNA positive group, the difference had statistical significance （P〈0. 05）. In the a- nalysis on the related factors in the children patients with EBV DNA non-negative conversion, the gender,WBC count and lymphocyte count had no significant correlation with EBV-DNA negative conversion（P〉 0. 05）, while interferon use, age and initial Ct demonstrated significant correlation with EBV-DNA non-negative conversion（P〈0.05）. Conclusion EBV infection can lead to dis- turbance of T cell subsets in children with IM,so clinic should adopt an active anti-virus treatment.

关 键 词：疱疹病毒4型 人 传染性单核细胞增多症 T细胞亚群 

分 类 号：R725.1[医药卫生—儿科]