右美托咪定与咪达唑仑复合舒芬太尼用于肝癌微波治疗术患者麻醉效果对比分析  

Comparative analysis of anesthetic effects of dexmedetomidine and midazolam combined with sufentanil in liver cancer patients undergoing microwave therapy

作　　者：梁桂金[1] 曹云[2] 

机构地区：[1]解放军第九四医院麻醉科,330000 [2]江西省人民医院呼吸内科

出　　处：《中国实用医药》2017年第21期4-6,共3页China Practical Medicine

摘　　要：目的对比分析右美托咪定与咪达唑仑复合舒芬太尼用于肝癌微波治疗术患者的麻醉效果。方法 160例行肝癌微波治疗术患者,根据数字随机表法分为咪达唑仑组和右美托咪定组,各80例。咪达唑仑组采用咪达唑仑复合舒芬太尼麻醉,右美托咪定组采用右美托咪定复合舒芬太尼麻醉。比较两组患者麻醉效果、舒芬太尼自控镇痛(PCA)按压次数、平均有效按压次数以及患者心动过速、高血压、呼吸抑制等并发症发生情况。结果右美托咪定组麻醉总有效率为92.50%,高于咪达唑仑组的75.00%,差异具有统计学意义(P<0.05)。两组患者心动过速、高血压、低血压和心动过缓发生情况比较差异无统计学意义(P>0.05);右美托咪定组呼吸抑制发生情况少于咪达唑仑组,差异具有统计学意义(P<0.05)。右美托咪定组舒芬太尼PCA按压次数、平均有效按压次数均少于咪达唑仑组,差异具有统计学意义(P<0.05)。结论右美托咪定复合舒芬太尼用于肝癌微波治疗术患者麻醉效果优于咪达唑仑复合舒芬太尼,可有效提高麻醉效果,减少舒芬太尼PCA按压次数、平均有效按压次数,减少呼吸抑制的发生,安全有效,值得推广。Objective To compare and analyze the anesthetic effects of dexmedetomidine and midazolam combined with sufentanil in liver cancer patients undergoing microwave therapy. Methods A total of 160 patients undergoing microwave therapy were divided by random number table method into midazolam group and dexmedetomidine group, with 80 cases in each group. The midazolam group received midazolam combined with sufentanil for anesthesia, and the dexmedetomidine group received dexmedetomidine combiried with sufentanil for anesthesia. Comparison were made on anesthesia effect, sufentanil patient controlled analgesia （PCA） compression times, average number of effective press and occurrence of tachycardia, hypertension and respiratory depression in two groups. Results The dexmedetomidine group had higher total anesthetic effective rate as 92.50% than 75.00% in the midazolam group, and the difference had statistical significance （P〈0.05）. Both groups had no statistically significant difference of incidence of tachycardia, hypertension, hypotension, and bradycardia （P〉0.05）. The dexmedetomidine group had lower occurrence of respiratory depression than the midazolam group, and the difference had statistical significance （P〈0.05）. The dexmedetomidine group had less sufentanil PCA compression times and average number of effective press than the midazolam group, and their difference had statistical significance （P〈0.05）. Conclusion Combination of dexmedetomidine and sufentanil shows better anesthetic effect than combination of midazolam and sufentanil, and it can effectively improve the anesthesia effect, reduce the number of sufentanil PCA pressing, average number of effective press and occurrence of respiratory depression. This method is safe and effective, and it is worth promoting.

关 键 词：右美托咪定 咪达唑仑 舒芬太尼 肝癌 微波治疗术 麻醉效果 

分 类 号：R614[医药卫生—麻醉学] R735.7[医药卫生—外科学]