不同糖皮质激素对胆道闭锁患儿术后治疗分析  

Analysis of different glucocorticoids in the treatment of biliary atresia in children

作　　者：张生格[1] 冯运红[1] 叶安[1] 

机构地区：[1]珠海市妇幼保健院小儿外科,519000

出　　处：《中国实用医药》2017年第22期13-15,共3页China Practical Medicine

基　　金：珠海市科技工贸和信息化局科立项课题(项目编号:02658811140624051)

摘　　要：目的分析不同糖皮质激素在胆道闭锁患儿术后应用的治疗效果。方法选取40例胆道闭锁患儿,按随机数字表分成试验组和对照组,各20例。两组术后均给予糖皮质激素,试验组使用甲基强的松龙,对照组使用地塞米松。对比两组术后1个月胆管炎发生率、总胆红素水平、直接胆红素水平。结果所有入选对象均较好的完成了术后治疗,无死亡及中途退出病例。试验组患儿的胆管炎发生率40.00%明显低于对照组的75.00%,差异具有统计学意义(P<0.05)。试验组患儿术后1个月总胆红素水平为(137.61±42.17)μmol/L,直接胆红素水平为(76.57±26.99)μmol/L,均显著低于对照组的(164.34±40.08)μmol/L、(95.83±25.14)μmol/L,差异具有统计学意义(P<0.05)。结论甲基强的松龙在胆道闭锁患儿术后对预防胆管炎的发生及降低血胆红素的治疗效果比地塞米松好。Objective To analyze the treatment effect of different glucocorticoids in the treatment of biliary atresia in children.Methods A total of 40 biliary atresia children were divided by random number table method into experimental group and control group,with 20 cases in each group.Both groups received glucocorticoids after treatment,and the experimental group was treated with methylprednisolone,and the control group was treated with dexamethasone.Comparison were made on incidence of cholangitis,total bilirubin and direct bilirubin level in 1 month after operation in two groups.Results All patients completed the postoperative treatment without death or withdrawal.The experimental group had obviously lower incidence of cholangitis as 40.00% than 75.00% in the control group,and the difference had statistical significance（P〈0.05）.The experimental group had total bilirubin level as（137.61±42.17） μmol/L and direct bilirubin level as（76.57±26.99） μmol/L in 1 month after operation,which were all significantly lower than（164.34±40.08） μmol/L and（95.83±25.14） μmol/L in the control group.Their difference had statistical significance（P〈0.05）.Conclusion Methylprednisolone shows better treatment effect in prevention of cholangitis and reduction of serum bilirubin for biliary atresia children.

关 键 词：甲基强的松龙 地塞米松 胆道闭锁 胆管炎 

分 类 号：R726.5[医药卫生—儿科]