盐酸坦洛新缓释胶囊联合氢氯噻嗪治疗输尿管结石的疗效系统评价  

Systematic evaluation on efficacy of tamsulosin hydrochloride sustained release capsules combined with hydrochlorothiazide in the treatment of ureteral calculi

作　　者：李力[1] 

机构地区：[1]山东省泰安市第一人民医院,271000

出　　处：《中国实用医药》2017年第22期100-102,共3页China Practical Medicine

摘　　要：目的系统性分析盐酸坦洛新缓释胶囊联合氢氯噻嗪治疗输尿管结石的临床疗效。方法 120例输尿管结石患者,随机分为观察组与对照组,各60例。两组患者均进行体外冲击波碎石治疗后,观察组给予盐酸坦洛新缓释胶囊联合氢氯噻嗪治疗,对照组单纯使用盐酸坦洛新缓释胶囊治疗,1个疗程后比较两组患者的结石排出效果、排出时间及不良反应发生率、止痛药物使用率以及用药后肾绞痛再发生率。结果观察组患者结石排出总有效率为96.67%,高于对照组的85.00%,差异有统计学意义(P<0.05)。观察组患者结石排出时间为(5.49±0.71)d,对照组为(9.66±1.21)d,观察组结石排出时间短于对照组,差异有统计学意义(P<0.05)。观察组止痛药物使用率以及用药后肾绞痛再发生率明显低于对照组,差异有统计学意义(P<0.05);两组患者的不良反应发生率比较差异无统计学意义(P>0.05)。结论盐酸坦洛新缓释胶囊联合氢氯噻嗪治疗输尿管结石能快速有效的促使结石排出,降低肾绞痛的再次发生率,减轻患者疼痛,其效果显著、安全有效,值得临床推广应用。Objective To systematically analyze the clinical efficacy of tamsulosin hydrochloride sustained release capsules combined with hydrochlorothiazide in the treatment of ureteral calculi.Methods A total of 120 ureteral calculi patients were randomly divided into observation group and control group,with 60 cases in each group.Both groups was treated with extracorporeal shock wave lithotripsy.The observation group also treated with tamsulosin hydrochloride sustained release capsules and hydrochlorothiazide,and the control group was treated with tamsulosin hydrochloride sustained release capsules.Comparison were made on stone expulsion effect,expulsion time and the incidence of adverse reactions,use rate of analgesic drugs and recurrence rate of renal colic after 1 course of treatment.Results The observation group had higher total effective rate in stone expulsion as 96.67% than 85.00% in the control group,and the difference had statistical significance（P〈0.05）.The observation group had ston expulsion time as（5.49±0.71） d,which was（9.66±1.21） d in the control group.The observation group had shorter stone expulsion time than the control group,and the difference had statistical significance（P〈0.05）.The observation group had obviously lower use rate of analgesic drugs and recurrence rate of renal colic than the control group,and their difference had statistical significance（P〈0.05）.Both groups had no statistically significant difference in incidence of adverse reactions（P〉0.05）.Conclusion Combination of tamsulosin hydrochloride sustained release capsules and hydrochlorothiazide in treating ureteral calculi can rapidly and effectively promote the expulsion of stones,reduce the recurrence rate of renal colic and relieve pain of patients.The effect is remarkable,safe and effective,and it is worthy of clinical popularization and application.

关 键 词：盐酸坦洛新缓释胶囊 氢氯噻嗪 输尿管结石 

分 类 号：R693.4[医药卫生—泌尿科学]