骨质疏松老年无牙颌患者全口义齿重衬与骨转化标志物的相关性  

Correlation between complete denture relines and serum bone turnover markers in elderly edentulous patients with osteoporosis

作　　者：毓天昊[1,2] 贾兴亚[1] 薛燕青 战德松[3] 阎旭[1,2] 

机构地区：[1]中国医科大学附属口腔医院干诊科,辽宁省沈阳市110002 [2]辽宁省口腔医学研究所口腔修复研究室,辽宁省沈阳市110002 [3]中国医科大学附属口腔医院修复二科,辽宁省沈阳市110002

出　　处：《中国组织工程研究》2017年第22期3513-3518,共6页Chinese Journal of Tissue Engineering Research

基　　金：辽宁省自然科学基金项目(2015020465)~~

摘　　要：背景:患有骨质疏松的老年无牙颌患者剩余牙槽嵴往往形态不佳,修复难度较大,目前尚无相应参考指标来反映此类患者剩余牙槽嵴吸收的情况和指示重衬等临床处理的频率。目的:分析患有骨质疏松的老年无牙颌患者全口义齿重衬频率与血清中骨钙素和Ⅰ型胶原羧基端交联肽两种骨转化标志物水平之间的相关性,以期为临床全口义齿修复提供参考。方法:按照纳入标准随机选取50例已行全口义齿修复并患有骨质疏松的老年无牙颌患者,对其进行相关问卷调查并查阅病史确定义齿重衬频率,同时采集患者空腹静脉血,采用电化学发光免疫法测量血清中骨钙素与Ⅰ型胶原羧基端交联肽的水平,通过Pearson相关性检验的统计学方法来分析重衬频率与骨钙素和Ⅰ型胶原羧基端交联肽之间的关系。结果与结论:患者的义齿重衬频率与血清中骨钙素水平之间有显著的正相关关系(r=0.517,P<0.01),而其与血清中Ⅰ型胶原羧基端交联肽水平并未观察到显著相关性(r=0.278,P=0.051>0.05),但二者有着相近的变化趋势。说明对于患有骨质疏松的老年无牙颌患者来说,检测血清中骨转化标志物水平有助于全口义齿修复疗效预后的评估和诊疗决策的制定。BACKGROUND： The residual alveolar ridge in edentulous patients with osteoporosis always presents with a poor shape, which increases the difficulty in complete denture restoration. Until now, there are no predictors for residual alveolar ridge resorption or guidelines on the frequency of denture relines. OBJECTIVE： To investigate the correlation between the frequency of complete denture relines and serum bone turnover markers, osteocalcin （OC） and cross-linked carboxy-terminal telopeptide of type I collagen （CTX）, in elderly edentulous patients with osteoporosis, in order to provide reference for complete denture repair. METHODS： According to inclusion criteria, 50 elderly edentulous patients with osteoporosis who had complete dentures were recruited in the study randomly. The frequency of complete denture relines was surveyed by related questionnaire and medical record, and the serum OC and CTX levels were detected by electrochemiluminescence immunoassay. Related data were analyzed statistically via Pearson correlation analysis. RESULTS AND CONCLUSION： It showed a strong positive correlation between the frequency of complete denture relines and the serum OC level （r=0.517, P 〈 0.01）. No significant correlation between relines frequency and the serum CTX level was observed （r=0.278, P=0.051 〉 0.05）, but it showed a similar tendency between them. These findings indicate that to detect the levels of serum bone turnover markers may be conducive to evaluating curative effect of complete dentures in elderly edentulous patients with osteoporosis as well as to making subsequent diagnostic and therapeutic strategies.

关 键 词：生物材料 口腔生物材料 骨质疏松 无牙颌 全口义齿 牙槽骨丧失 老年人 骨转化标志物 血清 骨密度 骨代谢疾病 骨改建 辽宁省自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]