纳米材料在关节置换内植物应用中的研究与特点（英文）  

A review on nano-materials as joint replacement implants

作　　者：王琳[1] 陈丹莹 张治宇[1] 张杭州[3] 

机构地区：[1]中国医科大学附属第四医院骨科,辽宁省沈阳市110032 [2]中国医科大学附属盛京医院康复科,辽宁省沈阳市110134 [3]中国医科大学附属第一医院骨科,辽宁省沈阳市110000

出　　处：《中国组织工程研究》2017年第22期3567-3575,共9页Chinese Journal of Tissue Engineering Research

基　　金：the National Natural Science Foundation of China,No.81671811,81501857~~

摘　　要：背景:关节置换后易出现植入物松动、脱位及感染。利用纳米技术制造的人工植入物为内置物的制备提供了一个新方向。目的:详细阐述纳米技术在改良关节置换植入物方面的相关研究进展。方法:应用计算机由第一作者在Pub Med数据库,以"joint replacement,artificial implant,nanotechnology,nano-materials,nanoscales,biocompatibility"为英文检索词,查找关于纳米技术及关节置换内植物实验研究相关文献,对资料进行筛选,排除重复研究及关联性较小的文献,保留与文章关联紧密的文献51篇。结果与结论:共纳入51篇英文文献,经综合分析整理,通过此综述详细介绍纳米材料相关的生物反应和与材料相关的一些组织相容性问题,以及已经用于改善纳米结构材料组织相容性的方法。BACKGROUND： Implant related problems such as loosening, dislocation and infection often come along with joint replacement. Nanotechnology provides a new insight into the preparation of joint replacement implants. OBJECTIVE： To elaborate the research progress of nanotechnology in improving joint replacement implants. METHODS： The first author used the computer to retrieve PubMed databases using the key words of “joint replacement, artificial implant, nanotechnology, nano-materials, nanoscales, biocompatibility” in English, to find relevant literature on nanotechnology and joint replacement implants. All data were primarily screened to exclude repeated and irrelevant articles, and finally 51 articles related to the study were retained. RESULTS AND CONCLUSION： Through reviewing these 51 articles, we make a detailed introduction about some of the biological responses that occur with nano-materials, and some of the biocompatibility problems that have been raised in relation to materials, as well as the ways that have been employed to improve biocompatibility of nano structured materials. But the long-term effect of nanotechnology on the human body is still worthy of further research in medicine or related fields.

关 键 词：生物材料 纳米材料 复合支架材料 关节置换 人工植入 纳米技术 纳米尺度 组织相容性 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]