赤芍不同提取物抗病毒活性研究  

Antiviral Activity of Different Extraction of Paeoniae Rubra Radix

作　　者：刘相文[1] 侯林[1] 范路路[1] 耿巧玉 孙纯勇 刘金安[1] 田景振[1] 

机构地区：[1]山东中医药大学,山东济南250355

出　　处：《辽宁中医药大学学报》2017年第8期34-36,共3页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家重大新药创制专项项目(2014ZX09509001);山东省高等学校中医药抗病毒协同创新中心课题(XTCX2014C01-01);山东省重点研发计划(重大关键技术及重点产业关键技术)-(2016CYJS08A01-8)

摘　　要：目的:研究赤芍不同提取物的抗病毒活性。方法:采用细胞体外抗病毒实验法,结合CPE法及CCK-8试剂盒,以TI值(治疗指数)为研究指标,以利巴韦林为阳性对照药,研究赤芍不同提取物对呼吸道合胞病毒(RSV)、柯萨奇病毒(COX-B5)、手足口病毒(EV71)的抑制作用。结果:甲醇超声提取物具有抗RSV、COX-B5的效果,且抗COX-B5效果较好,对COX-B5的TI值为12.042。结论:赤芍不同提取物具有体外抗RSV、COX-B5的活性。Objective ： To investigate the antiviral activity of different extraction of Paconiae Rubra Radix. Methods：Two different strains of viruses, including RSV, HSV-1, COX-BS, EVT1 were used for in-vitro antivirus experiment, and the antiviral activity of Paeoniae Rubra Radix were evaluated by the cytopathie effect （ CPE ）method and CCK-8. Thepapeutic indexes were calculated by the Reed-Muench method. Antivirus stability experiments ofPaeoniae Rubra Radix were carried out at the same time. Results： The TI of methanol ultrasound extraction was 12.042, it showed methanol ultrasound extraction was effective. Conclution： It indicated that different extraction of Paeoniae Rubra Radix have antiviral ac, tivity against RSV and COX-BS.

关 键 词：赤芍 抗病毒 呼吸道合胞病毒 柯萨奇病毒 

分 类 号：R285.5[医药卫生—中药学]