补肾化痰活血法对多囊卵巢综合征排卵障碍性不孕患者性激素、脂肪因子及子宫内膜容受性的影响  

Effect of Bushen Huatan Huoxue Method on Endometrial Tolerance in Patients with PCOS Ovulation Infertility

作　　者：曾倩[1] 张红霞[1] 王玉娜[1] 

机构地区：[1]沧州中西医结合医院东院区妇产科,河北沧州061000

出　　处：《四川中医》2017年第8期136-139,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：河北省中医药管理局科研项目(编号:2014354)

摘　　要：目的:观察补肾化痰活血法对多囊卵巢综合征(PCOS)排卵障碍性不孕患者子宫内膜容受性的影响。方法:选取我院诊收治的PCOS排卵障碍性不孕患者92例,按随机分对照组46例和研究组46例。对照组采用克罗米芬治疗;研究组采用克罗米芬联合补肾化痰活血法治疗,1个月经周期为1个疗程,共治疗3个疗程,治疗前后采用经阴道彩超(TV-CDFI)记录子宫内膜容受性,采取肘部静脉血测定性激素和脂肪细胞因子,同时对比临床疗效及安全性状况。结果:与治疗前比较,两组患者治疗后平均卵巢体积、子宫内膜PI、子宫内膜RI降低,子宫内膜厚度升高,治疗后血清LH、T降低,血清FSH、E_2升高,治疗后血清VF、LEP降低,血清APN升高(P<0.05);与对照组比较,研究组患者治疗后平均卵巢体积、子宫内膜PI、子宫内膜RI较低,子宫内膜厚度较高,治疗后血清LH、T较低,血清FSH、E_2较高,治疗后血清VF、LEP较低,血清APN较高(P<0.05);对照组治疗有效率为76.09%(35/46),研究组治疗有效率为91.31%(42/46),研究组高于对照组(P<0.05)。结论:补肾化痰活血法对于PCOS排卵障碍性不孕患者,显著改善子宫内膜容受性,调节内分泌水平,提高妊娠率,值得临床广泛推广。Objective： To investigate the effect of Bushen Huatan Huoxue Method on endometrial receptivity in patients with ESOS ovulation disorder. Methods： Forty-two patients with PCOS ovariectomized infertility were randomly divided into controlled group（ n = 46） and study group（ n = 46）. The controlled group was treated with clomiphene citrate. The study group was treated more with Bushen Huatan Huoxue Method and 2 groups were treated for 3 courses. The endometrial receptivity was recorded before and after treatment by transvaginal ultrasound（ TV-CDFI）,sex hormones and adipocytokines and clinical efficacy and safety status were compared. Results： Compared with before treatment,levels of the average ovarian volume,endometrial PI,endometrial RI decreased,levels of endometrial thickness increased after treatment,serumLH,T decreased,serum FSH,E_2 increased（ P〈0. 05）. Compared with the controlled group,levels of the average ovarian volume,endometrial PI and endometrial RI were lower in the study group,and the thickness of the endometrium was higher（ P〈0. 05）,serumLH and T were lower,serum FSH and E_2 were higher,serum VF and LEP were lower and serum APN was higher（ P〈0. 05）. The effective rate of the controlled groups was 76. 09%（ 35/46）,which was lower than the study group which was 91. 31%（ 42/46）,（ P〈0. 05）. Conclusion： Using Bushen Huatan Huoxue Decoction for treating PCOS ovulation disorder infertility patients,can significantly improve the endometrial receptivity,regulate endocrine levels,improve the pregnancy rate,worthy of clinical wide promotion.

关 键 词：补肾化痰活血法 PCOS 排卵障碍性不孕 子宫内膜容受性 

分 类 号：R711.75[医药卫生—妇产科学] R711.6[医药卫生—临床医学]