结核分枝杆菌免疫逃避机制研究进展  

Progress in immune escape mechanisms of Mycobacterium tuberculosis

作　　者：陈伟伟[1] 张冉冉[1] 曹雯[1] 陈晋[1] 

机构地区：[1]同济大学附属上海市肺科医院检验科,上海200433

出　　处：《中国人兽共患病学报》2017年第8期730-733,共4页Chinese Journal of Zoonoses

基　　金：国家自然科学基金(No.81371775)~~

摘　　要：结核病(Tuberculosis TB)主要由结核分枝杆菌(Mycobacterium tuberculosis,Mtb)感染引起,结核分枝杆菌在机体中长期存在与其逃避机体免疫杀伤机制密切相关。已发现的结核分枝杆菌免疫逃避机制包括阻止巨噬细胞吞噬溶酶体的成熟及酸化,抑制氧化应激反应,抑制细胞凋亡及自噬等。结核分枝杆菌逃避宿主免疫杀伤的机制错综复杂,目前尚未完全明了,本文就结核分枝杆菌免疫逃避机制做一综述,为其深入研究提供参考。Tuberculosis（TB）is mainly caused by Mycobacteriumtuberculosis（Mtb）,which in the body long-term existence is closely related to the immune escape mechanism.Mtb＇s immune escape mechanisms have been found to include prevention of phagosomal maturation and acidification of lysosomes,suppression of oxidative stress,inhibition of apoptosis and autophagy.Mtb immune escape mechanism to avoid the host is complex,not yet fully understood.This article focuses on Mtb immune escape mechanism as a review,is an in-depth study to provide a reference.

关 键 词：结核分枝杆菌 逃逸机制 免疫杀伤 

分 类 号：R378.91[医药卫生—病原生物学]