固体自微乳载体、固体化方法及稳定性研究进展  

Progresses on carrier,curing method and stability of solid self-microemulsifying drug delivery system

作　　者：孙娟娟[1] 张靖[1] 郭清清[1] 刘梦[1] 秦淑莲[1] 臧洪梅[1] 

机构地区：[1]安徽医科大学药学院,安徽合肥230032

出　　处：《中国医院药学杂志》2017年第16期1645-1648,1654,共5页Chinese Journal of Hospital Pharmacy

基　　金：安徽省自然科学基金青年基金项目(编号:1508085QH196);地方高校国家级大学生创新创业训练计划项目(编号:201510366038)

摘　　要：目的:对国内外近年来固体自微乳的载体、固体化方法及稳定性的研究进展进行综述,为该剂型的进一步研究和开发提供参考。方法:搜集国内外相关文献进行综合分析。结果:新型的载体材料和新的固体化方法可进一步提高固体自微乳的自乳化性能、药物的分散度,提高难溶性药物的溶出度和生物利用度,还可以改善药物的稳定性。结论:固体自微乳制剂具有微乳和固体制剂的双重优势,是非常具有研发前景的新型固体制剂,随着新型载体材料和固体化方法的开发,该剂型将得到广泛的应用。OBJECTIVE To review the progresses on carrier,curing method and stability of solid self-microemulsifying drug delivery system.METHODS Carrier,curing method and stability of solid self-microemulsions were discussed,and relevant literatures at home and abroad in recent years were consulted and summarized.RESULTS The new carrier materials and curing methods not only enhanced the performance of dispersion and self-emulsifying,but also improved the bioavailability and stability significantly.CONCLUSION Solid self-microemulsion has dual advantages of microemulsion and solid preparation.With the development of new carrier materials and curing methods,the solid self-microemulsifying drug delivery system will be used widely.

关 键 词：固体自乳化给药系统 固体化技术 生物利用度 

分 类 号：R944.9[医药卫生—药剂学]