中老年体检男性不同尿酸水平下骨代谢标志物的变化  

Correlation of Serum Uric Acid with Bone Metabolic Markers in Middle-aged Physical Examination Male

作　　者：陈说[1] 张帆[1] 彭卫群[1] 林远[1] 吴佩娴[1] 

机构地区：[1]北京大学深圳医院,广东深圳518036

出　　处：《中国医学创新》2017年第24期138-141,共4页Medical Innovation of China

基　　金：深圳市科技计划项目(JCYJ20140415162338822);深圳市科创委资助项目(JCY20140404154933580)

摘　　要：目的:观察中老年男性人群不同血尿酸水平下骨代谢生化指标的变化,探讨尿酸在骨代谢中的可能作用。方法:选取2015年1-12月在本院体检的114例中老年男性,根据血尿酸水平将研究人群分为高尿酸组57例(UA≥360μmol/L)和低尿酸组47例(UA<360μmol/L)。使用免疫分析测定骨转换指标,包括骨钙素(osteocalcin,OC)、Ⅰ型前胶原氨基端肽(procollagen typeⅠN-terminal propeptide,PⅠNP)、β胶原特殊序列(β-Cross Laps,β-CTX)以及活性维生素D3(25-OHD3),同时测定BMI、血压、空腹血糖、胰岛素、糖化血红蛋白、同型半胱氨酸,观察尿酸与各临床指标的相关性。结果:高尿酸组的BMI、DBP、FINS、Hcy、血尿酸水平、OC均高于低尿酸组,差异均有统计学意义(P<0.05),而两组的β-CTX、PINP、25-OHD3比较,差异均无统计学意义(P>0.05)。多元线性回归提示,血清尿酸水平与OC呈正相关(P<0.01)。结论:尿酸对中老年男性骨代谢发挥一定的保护作用,相关结论仍有待进一步研究证实。Objective：To investigate the correlation of uric acid（UA） levels with serum bone metabolic markers in middle-aged physical examination male.Method：From January 2015 to December 2015,114 male taken physical examination in our hospital were enrolled,and they were divided into high UA group（UA≥360 μmol/L,57 male） and low UA group（UA〈360 μmol/L） according to the serum UA level.Bone turnover markers including bone formation markers osteocalcin（OC）,procollagen type Ⅰ amino-terminal propeptide（PⅠNP）,bone resorption marker β-Cross Laps（β-CTX） and 25-hydroxy Vitamin D3（25-OHD3）were measured by ECL immunoassay.The correlation of UA levels with serum bone metabolic markers was observed.Result：BMI,DBP,FINS,Hcy,OC of high uric acid group were higher than those of low uric acid group,the differences were statistically significant（P〈0.05）,but there were no significant difference between β-CTX,PⅠNP,25-OHD3 of two groups（P〉0.05）.Regression analysis show serum uric acid was positive corrected with serum OC levels（P〈0.01）.Conclusion：UA plays a protective role in bone metabolism of middle-aged male,and the relative conclusions still need to be confirmed by further studies.

关 键 词：尿酸 骨代谢标志物 骨钙素 

分 类 号：R580[医药卫生—内分泌]