轻度认知损害证候分布特征文献研究  

Literature Research of Mild Cognitive Impairment Syndrome Distribution Characteristics

作　　者：高胤桐 田金洲[2] 时晶[2] 张然[3] 冯蕙裳 郭凯航 姜晓媛[1] 

机构地区：[1]北京中医药大学研究生院 [2]北京中医药大学东直门医院 [3]中国中医科学院望京医院

出　　处：《中医杂志》2017年第17期1503-1506,共4页Journal of Traditional Chinese Medicine

基　　金：北京市科技计划(Z151100003815021);北京市中医药"十病十药"成药性研究(CYX2014-10)

摘　　要：目的探讨轻度认知损害的中医证候特征。方法检索1990年1月至2014年12月中国知网、万方数据库、维普数据库,收集轻度认知损害证候研究类文献,对其中中医证型及证候要素进行统计分析,使用SPSS 17.0软件进行聚类分析并结合专家经验得出各证候要素的相关症状。结果共纳入32篇文献,经术语规范化后得出轻度认知损害有24个证型,出现频次前5位的分别为痰浊蒙窍证、肾精亏虚证、气血两虚证、热毒内盛证、瘀阻脑络证。病位类证候要素中肾和脑所占比率最高,分别为30.83%和30.00%;病因、病性类证候要素中气虚所占比率最高为16.50%。根据聚类分析结果并结合专家经验共提取出15个证候要素,其中包含69个症状。结论轻度认知损害中医证型以痰浊蒙窍证与肾精亏虚证为主,病位主要在肾、脑,病性为气虚。Objective To explore the Chinese medicine syndrome characteristics of mild cognitive impairment（ MCI）. Methods The papers of MCI syndrome research were reviewed and collected in China National Knowledge Infrastructure,Wan Fang Data and VIP Data from January of 1990 to December of 2014. Statistical analysis was made on the Chinese medicine syndrome types and syndrome factors. SPSS 17. 0 software was adopted to make cluster analysis. Combined with experts＇ experience,related symptoms to the syndrome factors were carried out. Results Totally 32 papers were included. After terminology normalization,there were 24 syndrome types of MCI. Top 5 syndromes with high frequency were syndrome of orifices confused by phlegm,syndrome of deficiency of kidney essence,syndrome of deficiency of both Qi and blood,syndrome of internal exuberance of heat toxin and syndrome of blood stasis blocking brain. In syndrome factors of disease location type,kidney and brain covered the highest proportion,30. 83% and 30. 00%. In syndrome factors of disease cause and character types,Qi deficiency covered the most,16. 50%. According to results of cluster analysis,combined with experts＇ experience,15 syndrome factors were extracted,including 69 symptoms. Conclusion Chinese medicine syndrome types of MCI were mainly syndrome of orifices confused by phlegm and syndrome of deficiency of kidney essence. The disease locations were mainly kidney and brain. The disease character was Qi deficiency.

关 键 词：轻度认知损害 证候要素 中医证型 文献研究 

分 类 号：R277.7[医药卫生—中医学]