6～8岁睡眠呼吸障碍患儿注意认知缺陷的ERP研究  

Attention cognitive deficiency in 6-8-year-old children with sleep disordered breathing：an ERP study

作　　者：浦旭姣 董选[2] 钱金强[1] 沈惠娟[2] 闻瑜 赵方乔[2] 易阳[1] 

机构地区：[1]南通大学附属常州儿童医院呼吸科,常州213003 [2]南通大学附属常州儿童医院健康研究中心,常州213003

出　　处：《中华行为医学与脑科学杂志》2017年第8期714-717,共4页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：基金项目：江苏省临床医学科技专项（BL2014037）;常州市卫生局重大课题（ZD201313）;常州市科技支撑计划（社会发展）项目（CE20145042）

摘　　要：目的探讨学龄期睡眠呼吸障碍（SDB）患儿注意认知缺陷的特征及神经电生理机制。方法选取6～8岁SDB患儿及正常对照组各20名，进行采用持续性操作测试（CPT-AX）（Go／Nogo）。记录SDB思儿与正常儿童行为学和ERP数据，比较两组Fz导联N2、P3的波幅和潜伏期。结果行为学数据显示，SDB组与正常组CPT-AX测试正确个数[（36．10±4．69）个，（35．05±3．49）个]，反应时间[（523．77±68．73）ms，（496．59±78．65）ms]，虚报个数[1．0（0．25，3．75）个，0．5（0．00，3．00）个]，差异无统计学意义（P〉0．05）；ERP数据显示，SDB组Go-P3波幅显著升高[（10．25±6．46）μV，（6．56±4．63）μV]（P〈0．05）；Go-P3潜伏期显著延长[（438．80±59．72）ms，（406．00±36．30）ms]（P〈0．05）；Nogo-N2波幅降低[（-12．46±4．75）nV，（-15．50μ3．82）IxV]（P〈0．05）。结论学龄早期6～8岁SDB患儿在注意执行过程需要消耗更多的资源与时间，引起一定的代偿反应，在冲突监测过程则资源调用不足，导致明显的抑制功能缺陷。Objective To investigate the cognitive dificiency characteristics and the neuro electro- physiological mechanism of sleep disordered breathing（ SDB ） in school-age children. Methods 20 cases of SDB children and 20 cases of normal group at 6-8 years old participated in the continue performance test （CPT-AX）. The amplitude and latency of N2,P3 of event related potentials（ERPs） were measured and ana- lysed at Fz leads, and the behavioral resuhs were recorded at the same time. Results There were no signifi- cant differences between SDB group and normal group in behavioral correct number （36.10±4.69 vs 35.05± 3.49） , the reaction time （ （ 523.77±68.73 ） ms vs （ 496.59±78.65 ） ms） and false alarm number （ 1.0 （ 0.25, 3.75） vs 0.5 （0.00,3.00））（all P〉 0. 05 ） . The SDB group showed significant increase in Go-P3 amplitudes compared with the normal group （ （ 10.25±6.46） μV vs （ 6.56± 4.63 ）μV, P〈 0.05 ）. The Go-P3 latency in SDB group was significantly prolonged than that in the normal group（（438.80±59.72） ms vs （406±36.30） ms,P〈0.05）, and the Nogo-N2 amplitude in SDB group significantly decreased compared with the normal group （（-12.46±4.75） μV vs （-15.50±3.82）pN,P〈0.05）. Conclusion The children aged 6 to 8 years old with sleep disordered breathing consume more resources and time to complete the attention process,like a compensatory response. And during the monitoring process there is a resource shortage that results in obvious defect in process of inhibition.

关 键 词：睡眠呼吸障碍 事件相关电位 儿童 Go-P3 Nogo-N2 执行功能 

分 类 号：R766[医药卫生—耳鼻咽喉科]