D、G组染色体随体多态性的临床生殖异常分析  

Clinical reproduction abnormality analysis of D-banding/G-banding chromosomal polymorphism

作　　者：陈竞茜[1] 马燕琳[1] 黎明红[1] 麦扬青[1] 龙平[1] 云天英[1] 孙超[1] 

机构地区：[1]海南医学院附属医院生殖中心,海南海口570102

出　　处：《中国优生与遗传杂志》2017年第8期44-45,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的讨论D、G组染色体随体多态性对生殖异常的影响及其产生的临床效应。方法在我中心行遗传咨询及辅助生殖的生殖异常夫妇4001对,进行外周血染色体制备及核型分析。结果检出D、G组染色体随体变异71例,其在人群中的发生率为0.89%(71/8002),其中13p+6例,占0.07%(6/8002),14p+11例,占0.14%(11/8002),15p+21例,占0.26%(21/8002),21p+21例,占0.26%(21/8002),22p+12例,占0.15%(12/8002)。结论 D、G组染色体多态性与不孕不育、反复自然流产、少弱精子症、生育智低儿、畸形儿等临床生殖异常有相关性。Objective：To discuss the influence of D-banding/G-banding chromosomal polymorphism to reproduction abnormality and generated clinical effect. Methods：To set up peripheral blood culture among 4001 cases of couples who have undertaken genetic counseling and assisted reproduction in our center. Results：71 cases of D-banding/G-banding abnormalities were detected among 8002 patients with the ratio of 0.89%（71/8002）. Among them,6 cases were 13p＋ with the ration of 0.07%（6/8002）,11 cases were 14p＋ with the ratio of 0.14%（11/8002）,21 cases were 15p＋ with the ratio of 0.26%（21/8002）,21 cases were 21p＋ with the ratio of 0.26%（21/8002）and 12 cases were 22p＋ with the ratio of 0.15%（12/8002）. Conclusion：D-banding/G-banding chromosomal polymorphism had relativity to clinical reproduction abnormalities such as infertility,recurrent spontaneous abortion,Oligoasthenospermia and reproduction of baby with low intelligence or birth defect,etc.

关 键 词：D、G组染色体 随体多态性 生殖异常 核型分析 

分 类 号：R596.1[医药卫生—内科学]