小剂量生长激素对卵巢低反应患者第二周期体外受精-胚胎移植治疗结局的影响  

Efficacy of low-dose growth hormone supplementation in thesecond IVF treatment cycle for poor ovarian responders

作　　者：郭莹 蒋向荣 杨娜 

机构地区：[1]秦皇岛市妇幼保健院,河北秦皇岛066000

出　　处：《中国优生与遗传杂志》2017年第8期111-113,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨第一周期体外受精-胚胎移植(IVF-ET)失败的卵巢低反应(POR)患者,第二周期添加小剂量生长激素后卵巢的反应性及IVF-ET的治疗结局。方法本研究回顾性分析了42例第一周期IVF-ET失败的POR患者,在促排卵方案及Gn使用剂量不变的前提下,主要观察添加小剂量GH对第二周期IVF-ET临床妊娠率(CPR)的影响,其次还包括获卵数、2PN受精率、优质胚胎数、可冻存胚胎数和种植率等。结果 GH组的临床妊娠率为33.34%,其优质胚胎数和冷冻胚胎数均高于对照组,且均有统计学差异(P<0.05)。结论小剂量生长激素可增加POR患者IVF-ET的成功率,减少治疗费用,降低不良反应,安全、经济、有效。Objective：To investigate whether Low-dose growth hormone supplementation affect the ovarian responseand outcome of the second IVF treatment cyclein patients for poor ovarian responders who failed in the frist IVF treatment cycle. Methods：A total of 42 poor responders toprevious IVF cycles,who failed to achieve pregnancy and were supplemented with lowdoses of GH in a subsequent cycle using the same gonadotropin dose and protocol. Our primaryendpoint was the clinical pregnancy rate（CPR）,considering secondary endpoints,the numberof retrieved oocytes,2PN fertilization rate,the number of top quality embryos,implantation,etc. Results：CPR in the GH group was 33.34%. Significant differences were observed for the GH group both in the number of top quality embryosandcryopreserved embryos. Conclusions：Despite thislow dose,we achieved excellent success rates in patients with a very poor prognosis,at areasonable cost and without side effects,which makes this a safe and costeffective alternative.

关 键 词：生长激素(GH) IVF-ET 卵巢低反应(POR) 临床妊娠率(CPR) 

分 类 号：R714.8[医药卫生—妇产科学]