258例无精子症患者血清生殖激素及抑制素B水平分析  

Analysis of reproductive hormone and inhibin B level in the serum of 258 patients with azoospermia

作　　者：刘安娜[1] 李文峰 

机构地区：[1]中国人民解放军第一七四医院检验科/厦门大学附属成功医院,福建厦门361003 [2]湖北省孝感市妇幼保健院生殖医学中心,湖北孝感432000

出　　处：《中国优生与遗传杂志》2017年第8期122-123,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨无精子症患者测定血清生殖激素及抑制素B的临床意义及价值。方法选择2016年1月至2016年12月期间在本院生殖中心就诊的无精子症患者258例,其中,非梗阻性无精子症155例,梗阻性无精子症103例,对照组为200例健康正常已生育男性。采用化学发光法对以上受试者进行血清PRL、FSH、LH、T和E2检测,同时采用ELISA法测定血清抑制素B水平。结果与对照组相比较,非梗阻性无精子症患者血清中抑制素B水平明显降低,FSH和LH水平明显升高,差异有统计学意义(P<0.01),而梗阻性无精子症患者与对照组相比较,差异无统计学意义(P>0.05)。结论血清生殖激素及抑制素B水平测定可作为非梗阻性无精子症和梗阻性无精子症的一项重要鉴别指标。Objective：To discuss the clinical significance and value of determining the level of serum reproductive hormone and inhibin B in patients with azoospermia. Methods：258 patients with azoospermia that had been admitted in the reproductive center of our hospital between January 2016 and December 2016 were included in the study;among them,there were 155 cases of non-obstructive azoospermia and 103 cases of obstructive azoospermia;200 healthy men who already have children were taken as the control group. Chemiluminescent immunoassay was adopted to determine PRL,FSH,LH,T and E2 in the serum of subjects and ELISA was used to determine inhibin B level in the serum. Results：Compared with the control group,inhibin B level in the serum of patients with non-obstructive azoospermia decreased evidently,FSH and LH level increased evidently,and the difference had statistical significance（P0.01）;there was no statistical significance in the difference between patients with obstructive azoospermia and healthy controls（P0.05）. Conclusions：The level of serum reproductive hormone and inhibin B can be taken as one important index to distinguish non-obstructive azoospermia and obstructive azoospermia.

关 键 词：生殖激素 抑制素B 非梗阻性无精子症 梗阻性无精子症 

分 类 号：R446.6[医药卫生—诊断学] R698.2[医药卫生—临床医学]