2,5-二芳基噻吩类化合物的高效绿色合成  

Efficient and green synthesis of 2,5-diarylated thiophenes

作　　者：郭孟萍[1] 陈博[1] 易艳萍[1] 申秀丽[1] GUO Meng-ping CHEN Bo YI Yan-ping SHEN Xiu-li(Institute of Coordination Catalysis, College of Chemistry and Biological Engineering, Yichun University, Yiehun 336000, Chin)

机构地区：[1]宜春学院化学与生物工程学院配位催化研究所,江西宜春336000

出　　处：《分子科学学报》2017年第4期309-312,共4页Journal of Molecular Science

基　　金：国家自然科学基金资助项目(21363026);江西省高校科技落地计划项目(KJLD13091)

摘　　要：无需金属和碱的催化,以1,4-二芳基取代-1,3-丁二炔与Na2S·9H2O为反应底物,80℃下DMF中合成了2,5-二芳基噻吩类化合物,考察了反应物苯环上电子效应和空间位阻对硫杂环化反应的影响.结果表明:反应物苯环上的吸电子或电子取代基团均对反应产物的分离产率影响不大;空间位阻较大的反应底物硫杂环化反应的收率略有降低,各种目标化合物产率为88%~100%.2,5-Diarylated thiophenes were synthesized via metal-free,base-free sulfur heterocyclization of 1,4-diaryl-1,3-diyne with Na2S·9H2O in DMF at 80 ℃ with a yield of 88%~100%.The influences of electronic effect and space hindrance on the sulfur heterocyclization were investigated.The results showed that the inconspicuousness difference was observed in isolated yield while the substituents containing electron-donating or electron-withdrawing in aryl-position of reactants were used,but slightly lower yield while the reactants with steric hindrance were tested.

关 键 词：2 5-二芳基噻吩 合成 硫杂环化反应 

分 类 号：O622[理学—有机化学]