一种咔唑类衍生物的合成及其探针性能研究  

Synthesis of carbazole derivative as fluorescent probe for copper(Ⅱ)ion

作　　者：张建刚[1] 谢晋鹏 张丽[1] 赵晋忠[1] 马望京[2] ZHANG Jian-gang XIE Jin-peng ZHANG Li ZHAO Jin-zhong MA Wang-jing(School of Arts and Sciences, Shanxi Agricultural University, Taigu 030801, China Technical Institute of Physics and Chemistry,Chinese Academy of Sciences, Beijing 100080, China)

机构地区：[1]山西农业大学文理学院,山西太谷030801 [2]中国科学院理化技术研究所,北京100080

出　　处：《分子科学学报》2017年第4期331-336,共6页Journal of Molecular Science

基　　金：中国博士后科学基金资助项目(2016M591410);山西农业大学博士启动基金资助项目(2014ZZ03)

摘　　要：用两步简便方法合成了基于咔唑基的荧光探针2,6-二(9-乙基咔唑-3氨甲基)-4-叔丁基苯酚,并对其光谱性能和离子选择性进行了研究.结果表明:在pH=7.4的体系中,该化合物对铜离子具有较强的选择性,铜离子的出现使得该探针在438nm处的荧光猝灭,且猝灭程度和铜离子浓度之间呈现良好的线性关系.A novel carbazole derivative,2,6-（9-ethyl carbazole-3-aminomethyl）-4-tert-butylphenol has been synthesized by reacting 3-amino-9-ethylcarbazole with 4-tertiary-butyl-2,6-dialdehyde phenol and characterized by 1 H NMR,IR spectroscopy and elemental analysis.2,6-（9-ethyl carbazole-3-aminomethyl）-4-tert-butylphenol displays strong fluorescence emission at 438 nm which is effectively and selectively quenched by Cu^（2＋） ion.Experimental results indicate that 2,6-（9-ethyl carbazole-3-aminomethyl）-4-tert-butylphenol binds to Cu^（2＋） ion with a 1∶1chemical stoichiometric ratio and the association constant is 2.24×104L·mol-1.2,6-（9-ethyl carbazole-3-aminomethyl）-4-tert-butylphenol can provide a rapid,selective and sensitive response to Cu^（2＋） ion in a linear dynamic range 1.0-20μmol/L at pH=7.4.Interference test shows that common mental ions have no interference to the Cu^（2＋） ion determination.It is anticipated that 2,6-（9-ethyl carbazole-3-aminomethyl）-4-tert-butylphenol can be a good candidate probe and has potential application for Cu^（2＋） determination in aqueous solution.

关 键 词：咔唑 CU2+ 荧光 

分 类 号：O622[理学—有机化学]