从幽门螺杆菌致病机制中看病因与病因推断中的辩证思维  

Dialectical Thinking on the Cause of the Disease in the Pathogenic Mchanism of Helicobacter pylori

作　　者：陈帅印[1] 李军[2] 张荣光[1] 段广才[1,3] CHEN Shuai-yin LI Jun ZHANG Rong-guang et al(College of Public Health, Zhengzhou University, Zhengzhou 450001 ,China)

机构地区：[1]郑州大学公共卫生学院,河南郑州450001 [2]河南省疾病预防控制中心,河南郑州450001 [3]新乡医学院分子诊断与医学检验技术河南省协同创新中心,河南新乡453003

出　　处：《医学与哲学（B）》2017年第7期75-76,79,共3页Medicine & Philosophy(B)

基　　金：2013年国家科技重大专项(2013ZX10004607);2016年郑州大学青年教师启动基金(32210273)

摘　　要：幽门螺杆菌是定植于胃部的细菌,人群感染率高达50%以上,幽门螺杆菌感染是慢性胃炎、胃十二指肠溃疡和胃癌及胃黏膜相关淋巴瘤的重要病因,但对幽门螺杆菌的致病机制研究并不透彻,影响临床结局的因素有很多,除了幽门螺杆菌感染和其分泌的毒力因子外,宿主的基因易感性、细胞因子的多态性和环境饮食等也是主要原因。通过分析幽门螺杆菌与胃癌的因果关系,可以在认识论的基础上把握疾病的本质规律,指导疾病诊疗。H.pylori is thought to colonize the gastric mucosa of more than 50% of the world＇s population.Infection with H.pylori is the strongest risk factor for chronic gastritis, gastric ulcer and gastric carcinoma.However, the mechanisms remain largely misunderstood.Many factors are known to contribute to the development of gastric carcinoma.Such as H.pylori chronic infections, gene susceptibility, polymorphism of cytokines and diet.Based on the understanding of mechanisms for H.pylori, it can help the clinician to realize the rules of disease and the disease treatment and prognosis judgment.

关 键 词：幽门螺杆菌 胃癌 病因 辩证法思想 

分 类 号：R378.2[医药卫生—病原生物学]