浸润性乳腺癌Ki-67表达与MRI形态学表现及ADC值间的相关性研究  

Correlative Study of MRI Morphological Features,ADC and Expression of Ki-67 in Invasive Breast Cancer

作　　者：李芹[1] 牛庆亮[2] 杜汉旺[2] 郑召龙 朱亚宁[2] 

机构地区：[1]潍坊医学院医学影像学系,261053 [2]山东省潍坊市中医院医学影像中心,261041

出　　处：《临床放射学杂志》2017年第8期1097-1100,共4页Journal of Clinical Radiology

摘　　要：目的探讨浸润性乳腺癌细胞增殖指数Ki-67表达与MRI形态学、表观扩散系数(ADC)之间的相关性。方法选取2013年9月至2015年12月间85例浸润性乳腺癌患者作为研究对象,所有患者术前均行常规MRI、扩散加权成像(DWI)及动态增强扫描,观察乳腺癌的MRI特征并与Ki-67表达情况进行对比分析。结果 85例浸润性乳腺癌Ki-67指数为5%~70%,其中高表达58例,低表达27例;无腋窝淋巴结转移59例Ki-67均值为(30.08±13.342)%,伴有淋巴结转移26例Ki-67均值为(40.19±12.999)%,两组Ki-67指数差异性显著(P=0.002,<0.05);肿瘤伴有坏死29例Ki-67均值为(38.79±13.070)%,无坏死56例Ki-67均值为(30.27±3.632)%,两组Ki-67指数差异性显著(P=0.007,<0.05);肿瘤边缘清晰组与边界毛糙组之间Ki-67表达的差异无统计学意义(P=0.106,>0.05);Ki-67指数与肿瘤大小、ADC值之间无显著相关性(P>0.05)。结论在浸润性乳腺癌的MRI形态学特征中,肿块坏死及腋窝淋巴结转移对于预测肿瘤细胞增殖指数Ki-67表达有重要意义。Objective To investigate the relationships between the expression of Ki-67,MRI morphological features and ADC in invasive breast cancer. Methods 86 cases with invasive breast cancer in our hospital from September 2013 to December 2015 were recruited in this study. All of the subjects were preoperatively examined with MRI（ plain scan,DWI and DCE-MRI）. The expression of Ki-67 detected by immunohistochemical methods was compared with the MRI morphological features and ADC. Results The expression of Ki-67 in patients with lymph node metastasis（ 40. 19 ± 12. 999%）and necrosis（ 38. 79 ± 13. 070%） were significantly higher than that without lymph node metastasis（ 30. 08 ± 13. 342%） and necrosis（ 30. 27 ± 13. 632%）（ P〈0. 05）. No relationships were found between the expression of Ki-67 and the size,shape,and ADC value of the tumor（ P〈0. 05）. Conclusion Lymphnode metastasis and necrosis in invasive breast cancer as displayed on MRI,play important roles in reflecting expression of Ki-67.

关 键 词：浸润性乳腺癌 病理学 Ki-67 磁共振成像 扩散加权成像 表观扩散系数 

分 类 号：R445.2[医药卫生—影像医学与核医学] R737.9[医药卫生—诊断学]