壳聚糖纳米粒子与乙基纤维素的混合静电纺丝及纺丝膜的血液相容性  

Electrospinning of chitosan nanoparticle together with ethyl cellulose and the blood compatibility of electrospun membrane

作　　者：董文苑 曾庆欢 尹学琼[1] 陈俊华[1] 刘海芳[2] 吕菊[1] 

机构地区：[1]海南大学海南省精细化工工程技术研究中心,海南大学,海口570228 [2]中南大学湘雅医学院附属海口医院,海口市人民医院,海口570208

出　　处：《化工新型材料》2017年第8期82-85,共4页New Chemical Materials

基　　金：国家自然科学基金项目(21264007、21466011)

摘　　要：将粒径2μm的壳聚糖(CTS)用机械球磨法球磨4h制备成粒径385nm的纳米颗粒(NCTS),再与乙基纤维素溶液(EC)混合静电纺丝制备了壳聚糖纳米颗粒/乙基纤维素纳米纤维膜(NCTS/EC),探讨了纺丝电压和接受距离对于纳米纤维膜表观形貌的影响,结果表明,通过控制纺丝电压和接受距离可以获得均匀无串珠的纳米纤维膜。接触角测试结果显示NCTS/EC疏水性能好。凝血时间和血小板吸附实验结果表明NCTS/EC具有较好的血液相容性。2μm chitosan was ball-milled for 4h to obtain chitosan nanopowders（NCTS）of 385 nm.NCTS was electrospun together with ethyl cellulose solution to prepare chitosan/ethyl cellulose nanofibrous membrane（NCTS/EC）.The effects of voltage and distance on the morphology of NCTS/EC were investigated.It found that the membrane with even fiber distribution was prepared through adjusting the electrospinning voltage and distance between the injector and acceptor.The water contact angle measurement expressed that NCTS/EC was hydrophobic and was practical for application in biosystem.The results of coagulation times and platelets adhesion experiments showed that NCTS/EC had good blood compatibility.

关 键 词：壳聚糖纳米颗粒 机械球磨 静电纺丝 乙基纤维素 血液相容性 

分 类 号：R318.08[医药卫生—生物医学工程]