室温放置时间对新鲜冰冻血浆质量参数的影响  

The changes of fresh frozen plasma parameters after its off from the cold chain

作　　者：陈会欣[1] 王顺[1] 

机构地区：[1]武汉市第一医院输血科,湖北武汉430022

出　　处：《中国输血杂志》2017年第7期699-701,共3页Chinese Journal of Blood Transfusion

基　　金：武汉市卫生计生委医疗卫生科研资助项目(WX15B16);湖北省卫生计生委采供血专项资助项目(WJ2015CB006)

摘　　要：目的探讨新鲜冰冻血浆脱离冷链后血浆相关参数的变化。方法将待测新鲜冰冻血浆设为1个对照组(室温下放置0 h)和5个实验组(实验1组、2组、3组、4组和5组,室温下分别放置0.5、2、4、8和12 h),分别检测各组PT、INR、APTT、Fbg、AT、FⅧ∶C、FⅤ、蛋白C等指标的变化。结果实验4组和实验5组血浆中的FⅧ∶C、AT、PC与对照组相比均明显下降(P<0.05)。但各实验组中的APTT、PT、INR、Fbg和FⅤ与对照组比较,均无统计学差异(P>0.05)。结论新鲜冰冻血浆水浴融化后在室温放置时间超过8 h,其包含的抗凝成分(包括AT、PC)及促凝成分(凝血因子FⅧ∶C)均减少,但在室温下放置12 h内其APTT、PT、INR、Fbg和FⅤ测定值无明显变化。Objective To discuss the changes of the quality of the fresh frozen plasma, which leaved refrigerator and it was out of the cold chain. Method The fresh frozen plasma was placed at the room temperature, in six different periods, that is 0, 0. 5, 2, 4 h, 8, and 12 hours.The prothrombin time, activated partial thrombin live enzymes time, fibrinogen and factor FV, factor FⅧ, antithrombin（AT） and protein C were tested on each point. Results In the fourth group and the fifth group, the Ⅷ,AT, and protein C were statistically lower compared with the controls （P〈0.05）. But there were no obvious changes of APTY, PT, INR, Fbg and FVwhen placed at room temperature for 12 hours. Conclusion After the fresh frozen plasma placed at room temperature for more than 8 hours, the FVⅧ ： C, AT and protein C were significantly lower compared with the control group. But they have no obvious changes of APTT, PT, INR, Fbg and FVwhen placed at room temperature for 12 hours.

关 键 词：新鲜冰冻血浆 室温 血液质量 

分 类 号：R457.14[医药卫生—治疗学]