贮存式自身输血在异基因造血干细胞移植供者中的应用  

The application of predeposit autotransfusion in hematopoietic stem cell donors

作　　者：王文婷[1] 郑妍[1] 魏华[1] 穆士杰[1] 

机构地区：[1]第四军医大学唐都医院输血科,陕西西安710038

出　　处：《中国输血杂志》2017年第7期721-723,共3页Chinese Journal of Blood Transfusion

摘　　要：目的探寻贮存式自身输血在异基因造血干细胞移植供者中的应用效果。方法回顾性分析2013-2016年本院进行贮存式自身输血的127例异基因造血干细胞移植供者的造血干细胞采集及自体血回输情况。结果 127例供者共采集自体血70 550 m L,仅2例出现轻度献血反应,不良反应发生率为1.6%(2/127);采集骨髓血100 159m L。117例供者骨髓血采集前WBC(27.02±8.21)×1010/L、Plt(213.19±62.42)×109/L、RBC(4.31±0.44)×1012/L、Hb(131.53±14.53)g/L,自体血回输后1d WBC(35.85±9.08)×1010/L、Plt(188.34±50.24)×109/L、RBC(4.02±0.41)×1012/L、Hb(122.60±13.48)g/L。自体血回输后1 d造血干细胞供者WBC明显高于采髓前(P<0.05),Plt、RBC、Hb明显减低(P<0.05)。结论贮存式自身输血能节约血液资源,防止输血相关疾病发生,可应用于造血干细胞供者。Objective To explore the effect of predepositautotransfusion in hematopoietic stem cell donors.Methods 127donors of hematopoietic stem cell wereretrospectively analyzed from 2013 to 2016, whenhematopoietic stem ceils collection and autologous blood transfusion. Results Collection autologous blood 70 550 mL by 127 donors, and 2 cases had mild blood donation reaction,at a rate of 1.6% （2/127）. Collectionbone marrow stem hematopoietic stem cell 100 159 mL. The detection results were WBC （27.02±8.21） × 1010/L、Plt（213.19±62.42） × 109/L,RBC（4. 31±0. 44） × 1012/L,Hb（ 131.53 ±14. 53）g/L, from 117 donors beforespinal cord extraction. The detection resuhs were WBC （35.85±9. 08）×1010/L, Pit （ 188.34±50. 24 ） ×109/L, RBC （ 4. 02± 0.41 ） × 10112：/L, Hb （ 122. 60 ± 13.48 ） g/L, from 117 donorsafter autologous blood transfusion in one day. Compared with donors after autologous blood transfusion in one day, WBC was higher before spinal cord extraction（ P〈0. 05）, Plt RBC and Hb was significantly decree （P〈0. 05）. Conclusion Preoperative autologous blood donation can save blood and prevent blood-borne infectious disease, which can used in Hematopoietic stem cell donor.

关 键 词：贮存式自身输血 造血干细胞供者 

分 类 号：R457.1[医药卫生—治疗学]