上海地区无偿献血者血液中不规则抗体的调查  

Investigation of irregular antibodies in blood samples from donors in Shanghai area

作　　者：蔡茵[1] 曹斌[1] 周喆[1] 王中英[1] 王莉[1] 郑岚[1] 周国平[1] 

机构地区：[1]上海市血液中心,上海200051

出　　处：《中国输血杂志》2017年第7期791-793,共3页Chinese Journal of Blood Transfusion

摘　　要：目的对上海地区无偿献血者血液中不规则抗体进行常规筛查,在进一步提高血液安全同时,也为寻找一个适合于血站大规模常规开展不规则抗体的筛查方法,提供参考依据。方法采用盐水介质与微量板木瓜酶法相结合的方法,对824 072例献血者进行不规则抗体筛查。结果 824 072例献血者血液样本中共检测出不规则抗体阳性1 246例,阳性率1.51‰。结论筛查无偿献血者血液中不规则抗体,可有效降低或避免溶血性输血反应;盐水介质与微量板木瓜酶法相结合的方法是适合血站大规模常规开展不规则抗体筛查的有效方法。Objective With the purpose of further improving blood safety and providing the reference basis for a strategy suitable for large-scale routine screening of irregular antibodies in blood service, the irregular antibodies in blood samples from donors in Shanghai area were investigated.Method Irregular blood antibodies were screened in 824 072 blood donors through combined method of saline medium and microplate papain.Result 1 246 samples of blood donors were detected with irregular antibodies among the total 824 072 samples which indicate the positive rate of 1.51%o.Conclusion Screening of ir- regular antibodies in blood samples from donors can effectively reduce or avoid hemolytic transfusion reactions. The combined method of saline medium and microplate papain is an effective method for large-scale routine screening of irregular antibodies in blood service.

关 键 词：不规则抗体 无偿献血者 微量板木瓜酶法 盐水介质 

分 类 号：R193.3[医药卫生—卫生事业管理] R457.11[医药卫生—公共卫生与预防医学]