强直性脊柱炎与细胞毒性T细胞相关抗原-4基因多态性的Meta分析  

Association between cytotoxic T lymphocyte associated antigen-4 gene polymorphism and ankylosing spondylitis susceptibility： a meta-analysis

作　　者：刘晓敏[1] 陈银河[2] 

机构地区：[1]安徽省立医院西区(安徽省肿瘤医院)急诊内科,合肥230031 [2]安徽医科大学附属阜阳医院骨科

出　　处：《中华风湿病学杂志》2017年第8期547-552,共6页Chinese Journal of Rheumatology

摘　　要：目的探讨细胞毒性T细胞相关抗原（CTLA）．4基因单核苷酸多态性（SNP）与AS易感性的关联情况。方法通过中国生物医学文献数据库、中国期刊网全文数据库、万方、维普,PubMed、CochraneLibrary、OvidSP、Wiley Online Library、Elsevier Science Direct、Springer Link数据库检索CTLA-4基因与AS相关的病例．对照研究，利用Stata12．0软件x^2检验计算其基因型和等位基因与As的关联性。结果共纳入7篇CTLA-4基因第1外显子＋49A／G位点（rs231775）SNP与AS的文献，包含1119例AS病例和995例对照（健康人群或非AS患者）。Meta分析结果显示rs231775SNP在隐性模型、显性模型、共显性模型、相加模型和等位基因模型下与AS的关联性差异均无统计学意义。共纳入5篇CTLA-4基因启动子区．318C/T位点（rs5742909）SNP与AS的文献，包含635例AS病例和512例对照。Meta分析结果显示rs5742909SNP在隐性模型和相加模型下与AS的关联性无统计学意义，在显性模型[OR=1．651，95％CI（1．052，2．590），P=0．029]、共显性模型[OR=0．621，95％CI（0．403，0．957），P=O．031]和等位基因模型[OR=1．587，95％CI（1．068，2．357），P=0．0223下与AS的关联性有统计学意义。结论CTLA-4基因rs231775SNP与AS尚无关联性，rs5742909SNP与AS有关联，rs5742909C→T的突变可能导致罹患AS的风险增高。Objective To explore the association between cytotoxic T lymphocyte associated antigen-4 （CTLA-4） gene polymorphism and susceptibility to ankylosing spondylitis （AS）. Methods The case-control studies from Chinese Biomedical Database, Chinese National Knowledge Infrastructure, Wanfang, Weipu, PubMed, Cochrane Library, OvidSP, Wiley Online Library, Elsevier Science Direct, Springer Link databases for the association of CTLA-4 gene polymorphism with AS. The association strength was assessed with chi-squared test by Stata 12.0 software. Results Seven references of CTLA-4 gene ＋49A/G （rs231775） polymorphism Were enrolled which included 1 119 AS patients and 995 controls （healthy subjects or non-AS patients）, which showed that there were no statistical difference between AS and control groups under recessive, dominant, co- dominant, additive and allele gene models. Five references of CTLA-4 gene -318C/T （rs5742909） polymorphism were enrolled which included 635 AS patients and 512 controls, which showed that there were no statistical difference between AS and control groups under recessive and additive gene models; however, there were statistical difference between AS and control groups under dominant model [0R=1.651, 95%CI （1.052, 2.590）, P=0.029], co-dominant model [OR=0.621, 95%CI （0.4031 0.957）, P=0.031] and allele model [OR=1.587, 95%CI （1.068, 2.357）, P=0.022]. Conclusion The meta analysis reveal that CTLA-4 gene rs231775 single nucleotide polymorphism is not associated with the susceptibility to AS; rs5742909 SNP is associated with the susceptibility to AS, which suggests that C→T mutation increases the risk of AS.

关 键 词：脊柱炎 强直性 T淋巴细胞 细胞毒性 多态性 单核苷酸 META分析 

分 类 号：R593.23[医药卫生—内科学]