坏死性淋巴结炎与干扰素γ诱导蛋白10、单核因子、FasL  

Necrotizing lymphadenitis and interferon γ inducible protein 10,monokine,FasL

作　　者：黄子慧[1] 张国英[1] 洪练青[1] 钮晓红[1] 靳汝辉[1] 

机构地区：[1]南京中医药大学附属南京市中西医结合医院,江苏南京210014

出　　处：《中华中医药学刊》2017年第9期2441-2443,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：南京市科技局科技发展计划项目(201201058)

摘　　要：目的:观察3型坏死性淋巴结炎患者的临床表现,探讨干扰素γ诱导蛋白10、单核因子、Fas L在3型坏死性淋巴结炎患者发病中的作用。方法:将HNL患者根据病理组织学分成增生(PT)、坏死(NT)和黄色瘤型(XT)3组,观察其临床表现,记录中医证候积分;抽取健康对照组和3组HNL患者外周血,用ELISA法检测血清IP-10、Mig、Fas L的含量。结果:PT、NT患者的中医症候积分明显高于XT患者,前两组与后者相比,有显著性差异(P<0.05);坏死性淋巴结炎患者血清IP-10、Mig、Fas L均明显高于健康对照组(P<0.01);PT、NT2型血清IP-10、Mig、Fas L明显高于XT型,差异有显著性意义(P<0.05);IP-10、Mig、Fas L与淋巴结肿痛、体征呈正相关。结论:3组患者的临床表现存在差异;IP-10、Mig、Fas L可能参与了坏死性淋巴结炎发病过程,并与临床症状有相关性。Objective： To observe clinical manifestation of type Ⅲ necrotizing lymphadenitis patients,and discuss interferon γ inducible protein 10,monokine,and FasL＇s function in the incidence of type Ⅲ necrotizing lymphadenitis on patients. Method： HNL patients were divided into three groups by proliferation（ PT）,necrosis（ NT） and xanthoma（ XT） based on pathologic histology,their clinical manifestations were observed,and a Chinese medicine symptom score was recorded on each group; then peripheral blood samples were taken from each of the healthy control group and 3groups of HNL patients,which were further examined for serum IP-10,Mig and FasL contents using ELISA method.Result： The Chinese medicine symptom scores of PT and NT group patients were significantly higher than that of XT group patients,i. e.,significant difference arose（ P 0. 05） when comparing the first two groups with the latter; serum IP-10,Mig and FasL of necrotizing pymphadenidis patients were all higher than that of the healthy control group（ P 0. 01）,serum IP-10,Mig and FasL of PT and NT group patients were significantly higher than that of XT group patients,and the difference was statistically significant（ P 0. 05）. IP-10,Mig and FasL appeared to be positively correlated to lymphadenectasis and accompanying pain as well as physical signs. Conclusion： Difference existed amongst clinical manifestation of 3 groups of patients; IP-10,Mig and FasL might be involved in the incidence of necrotizing lymphadenitis,and are correlated to the clinical manifestations.

关 键 词：3型坏死性淋巴结炎 干扰素γ诱导蛋白10 单核因子 FASL 

分 类 号：R632.6[医药卫生—外科学]