窄谱抗菌肽的筛选及其溶血性分析  

Screening of antimicrobial peptide with narrow spectrum and analysis of hemolysis

作　　者：杭柏林[1] 徐军[1] 李杰[2] 赵雪芹[1] 魏晓晓[1] 张慧辉[1] 胡建和[1] 

机构地区：[1]河南科技学院动物科技学院,河南新乡453003 [2]新乡市畜产品质量监测检验中心,河南新乡453003

出　　处：《河南科技学院学报（自然科学版）》2017年第4期37-40,共4页Journal of Henan Institute of Science and Technology(Natural Science Edition)

基　　金：国家自然科学基金(31672559);河南省高校科技创新团队支持计划(15IRTSTHN);河南科技学院高层次人才启动项目(2014020);河南科技学院"百农英才"创新项目(BNYC2015-2-07;BNYC2015-2-09)

摘　　要：通过抗菌活性试验筛选了具有窄谱特性的抗菌肽,并分析了其溶血性.结果表明:抗菌肽C仅对大肠杆菌和金黄色葡萄球菌具有抗菌活性,而对其他6种革兰阴性菌、2种革兰阳性菌和3种真菌没有抗菌活性,对兔红细胞有较低的溶血性.结果为临床用药提供了帮助.To screen the antimicrobial peptide with narrow spectrum,the antimicrobial peptides were screened with narrow spectrum characteristics through the antibacterial activity test,and its hemolytisis was analyzed.The results showed that the antibacterial peptide C had antibacterial activity only on Escherichia coli and Staphylococcus aureus, but had no antibacterial activity on the other six kinds of Gram-negative bacteria,two kinds of Gram-positive bacteria and three kinds of fungi,and had lower hemolytic on rabbit red blood cells.The result provides help for chnical medication.

关 键 词：窄谱抗菌肽 筛选 溶血性 抗菌活性 

分 类 号：S859[农业科学—临床兽医学]