巴氏芽孢八叠球菌及相关微生物的生物矿化的分子机理与应用  

Mechanism and Applications of Bio-mineralization Induced by Sporosarcina pasteurii and Related Microorganisms

作　　者：吴洋[1,2,3,4] 练继建[5] 闫玥[5] 齐浩[1,2,3,4] 

机构地区：[1]天津大学化工学院,天津300072 [2]系统生物工程教育部重点实验室,天津300072 [3]天津大学化工协同创新中心合成生物学平台,天津300072 [4]天津大学前沿技术研究院,天津300072 [5]天津大学水利工程仿真与安全国家重点实验室,天津300072

出　　处：《中国生物工程杂志》2017年第8期96-103,共8页China Biotechnology

基　　金：国家自然科学基金资助项目(21476167)

摘　　要：巴氏芽孢八叠球菌是迄今为止所知的利用尿素降解进行生物矿化的最为高效的微生物系统之一,基于其碳酸钙生物矿化形成的"超强能力",巴氏芽孢八叠球菌已经被成功地应用于沙石、土壤等生物固化中,成为一种全新的、具有极大潜力的生物建筑辅助技术,被称为"生物水泥"。由于巴氏芽孢八叠球菌分离自土壤,没有病原性并具有极好的环境友好性。近年来,其应用领域被拓展到环境治理乃至健康医疗领域,成为全新的研究热点。然而,与应用研究相比,人们对巴氏芽孢八叠球菌生物矿化背后的分子机理还知之甚少。因此,这里针对迄今为止国内外对于巴氏芽孢八叠球菌生物矿化相关的分子机理的研究进行分析介绍,在此基础上综述了包括建工、环境、及医疗健康领域在内的巴氏芽孢八叠球菌的应用,希望能够促进对于该球菌矿化的研究。As known so far,Sporosarcina pasteurii,or formally termed as Bacillus pasteurii,was considered as one of the most efficient biosystem which is capable of inducing biological mineralization through breaking down urea. Taking advantage of the ＇super power＇ of bio-mineralization,Sporosarcina pasteurii has been successfully utilized in application of solidifying sand as a novel biological construction technology,termed as＇bio-cementation＇. Due to the nature of Sporosarcina pasteurii isolated from soil,non-pathogenicity has been observed,it was considered as a very environmentally friendly method. Recently,Sporosarcina pasteurii has been further applied into fields including environmental improvement and biomedicine. However,the mechanism under the strong Sporosarcina pasteurii mediated bio-mineralization is still not well understood. Here,the knowledge and the up-to-date studies about the biological mechanism of Sporosarcina pasteurii mediated bio-mineralization,and the utilization in construction,environment,and biomedicine are reviewed.

关 键 词：生物矿化 巴氏芽孢八叠球菌 脲酶 

分 类 号：Q819[生物学—生物工程]