苯胺类化合物与丙二酸二乙酯的酰胺化反应  

The Amidation Between Anilines and Diethyl Malonate

作　　者：宋璐娜 于静文[1] 

机构地区：[1]山西医科大学晋祠学院基础医学部,山西太原030025

出　　处：《太原师范学院学报（自然科学版）》2017年第2期83-86,共4页Journal of Taiyuan Normal University:Natural Science Edition

摘　　要：分析一种苯胺类化合物与丙二酸二乙酯的酰胺化反应.该合成方法以操作简便、无溶剂和无催化剂为主要特色.此外,实验证明电子效应对该反应的影响较小.得到的7种产物均可达到中等收率(65%~75%),并通过核磁共振氢谱、核磁共振碳谱对产物的结构进行了表征.A novel amidation between anilines and diethyl malonate has been reported. Operational simplicity, solvent-free and catalyst-free media are the main highlights. In addition, the electronic effect has less effect on this reaction. Seven different products were obtained successfully in moderate yields （65%-75%） and the structure of products were characterized by ^1H NMR spectra and ^13C NMR spectra.

关 键 词：合成方法 酰胺化 无溶剂 无催化剂 苯胺 丙二酸二乙 

分 类 号：O62[理学—有机化学]