基于TRPM8通道研究薄荷醇对哮喘小鼠气道反应性及肺组织病理学的影响  

Investigation for Effects of Menthol on Airway Responsiveness and Lung Pathology in Asthmatic Mice Based on TRPM8 Channel

作　　者：郅琳[1] 臧文华[1] 张雪鹏[1] 

机构地区：[1]南阳理工学院,南阳473004

出　　处：《科学技术与工程》2017年第24期9-12,共4页Science Technology and Engineering

基　　金：高等学校博士学科点专项科研基金(20103107110008)资助

摘　　要：研究TRPM8通道在支气管哮喘发病机制中的作用,以及薄荷醇(Menthol)对哮喘小鼠气道反应性及肺组织病理学的影响。观察Menthol对TRPM8野生型(+/+)和敲除型(-/-)小鼠气道反应性及肺组织病理学改变的影响。Menthol可缓解肺组织病理进程,而Menthol对TRPM8-/-型哮喘小鼠无改善作用。To study the role of TRPM8 channel in the pathogenesis of bronchial asthma and the effect of Menthol on airway responsiveness and lung pathology in asthmatic mice,Menthol was effected on wild type TRPM8（＋/＋）and knockout（-/-） the changes of lung tissue and airway pathological reaction. The Results was that Menthol could relieve the pathological process of lung tissue,but Menthol had no effect on TRPM8-/-asthmatic mice.

关 键 词：TRPM8通道 支气管哮喘 薄荷醇 

分 类 号：R256.12[医药卫生—中医内科学]