加巴喷丁和普瑞巴林用于治疗慢性瘙痒  

Gabapentin and pregabalin for the treatment of chronic pruritus

作　　者：Matsuda KM Sharma D Schonfeld AR Kwatra SG 薛如君 张锡宝 

出　　处：《皮肤性病诊疗学杂志》2017年第4期300-300,共1页Journal of Diagnosis and Therapy on Dermato-venereology

摘　　要：瘙痒持续6周可定义为慢性瘙痒,慢性瘙痒是一种难以治疗的自主症状。当局部治疗和口服抗组胺药物对患者无效时,临床医师需考虑使用神经活性药物等其他治疗手段。加巴喷丁和普瑞巴林最初作为抗癫痫药物用于治疗神经性疼痛,如带状疱疹后遗神经痛、糖尿病性神经病变,这两种药物作用于痛觉和痒觉的信号传导途径,也被用于探索性治疗缓解慢性瘙痒。Chronic pruritus is a distressing symptom that is often refractory to treatment. Patients frequently fail topical therapies and oral over-the-counter antihistamines, prompting the clinician to consider alternative therapies such as neuroactive agents. Herein, the use of gabapentin and pregabalin, 2 medications well known for treating neuropathic pain and epilepsy that are occasionally used for relieving chronic pruritus is explored. The findings from original sources published to date to evaluate the use of gabapentin and pregabalin as antipruritic agents are explored. They are found to be promising alternative treatments for the relief of several forms of chronic pruritus, particularly uremic pruritus and neuropathic or neurogenic itch, in patients who fail conservative therapies.

关 键 词：局部治疗 普瑞巴林 加巴喷丁 瘙痒 慢性 带状疱疹后遗神经痛 糖尿病性神经病变 神经活性药物 

分 类 号：R758.31[医药卫生—皮肤病学与性病学]