甲氨蝶呤联合米非司酮治疗输卵管妊娠的临床效果分析  

Clinical analysis of methotrexate combined with mifepristone in the treatment of tubal pregnancy

作　　者：张波兰 

机构地区：[1]广东省揭阳市揭西县人民医院,广东揭阳515400

出　　处：《吉林医学》2017年第9期1639-1640,共2页Jilin Medical Journal

摘　　要：目的:探究甲氨蝶呤联合米非司酮治疗输卵管妊娠的临床疗效。方法选取输卵管妊娠患者78例,随机分为对照组和研究组,对照组患给予甲氨蝶呤治疗,研究组在对照组治疗的基础上同时给予米非司酮进行治疗,连续治疗5 d后,测定并比较两组患者的血清β-HGG水平以及盆腔包块直径,同时比较两组患者的临床疗效和不良反应发生率。结果:治疗后两组患者血清β-HGG水平以及盆腔包块直径均有所下降,且研究组患者改善程度更加明显(P<0.05)。同时研究组患者的临床疗效和不良反应发生率都明显低于对照组患者(P<0.05)。结论:甲氨蝶呤联合米非司酮治疗输卵管妊娠临床疗效显著,不良反应发生率低,是一种有效、可行、安全的保守治疗方法,建议临床上推广应用。Objective To investigate the clinical efficacy of methotrexate combined with mifepristone in the treatment of tubal pregnancy. Method 78 patients with tubal pregnancy were selected and randomly divided into control group and study group. Patients of control group received methotrexate treatment and of study group received mifepristone on the basis of control group. After 5 consecutive days of treatment,the serum β-HGG level and pelvic mass were measured and compared. The clinical efficacy and the incidence of adverse reactions were compared between the two groups. Results After treatment,serum β-HGG levels and pelvic mass were decreased of both groups,but the improvement was more pronounced in the study group（ P 〈 0. 05）.At the same time,the clinical efficacy and the incidence of adverse reactions of the study were significantly lower than that of control group（ P 〈 0. 05）. Conclusion The efficacy of methotrexate combined with mifepristone in the treatment of tubal pregnancy is significant and the incidence of adverse reactions is low,which is an effective,feasible and safe conservative treatment method,suggesting to be widely used in clinical practice.

关 键 词：甲氨蝶呤 米非司酮 输卵管妊娠 

分 类 号：R714.221[医药卫生—妇产科学]